Physiological effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein A

American Journal of Physiology. Lung Cellular and Molecular Physiology
Timothy C BaileyRuud A W Veldhuizen

Abstract

Oxidative damage to surfactant can decrease lung function in vivo. In the current study, our two objectives were: 1) to examine whether the adverse effects of oxidized surfactant would be accentuated in animals exposed to high tidal volume ventilation, and 2) to test whether supplementation with surfactant protein A (SP-A) could improve the function of oxidized surfactant in vivo. The first objective was addressed by evaluating the response of surfactant-deficient rats administered normal or oxidized surfactant and then subjected to low tidal volume (6 ml/kg) or high tidal volume (12 ml/kg) mechanical ventilation. Under low tidal volume conditions, rats administered oxidized surfactant had impaired lung function, as determined by lung compliance and arterial blood gas analysis, compared with nonoxidized controls. Animals subjected to high tidal volume ventilation had impaired lung function compared with low tidal volume groups, regardless of the oxidative status of the surfactant. The second experiment demonstrated a significantly superior physiological response in surfactant-deficient rats receiving SP-A containing oxidized surfactant compared with oxidized surfactant. Lavage analysis at the end of the in vivo experimentation ...Continue Reading

References

Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G Enhorning
Dec 1, 1991·The Journal of Clinical Investigation·T J GregoryT M Hyers
Feb 1, 1990·Chemistry and Physics of Lipids·B A HolmR H Notter
Dec 1, 1989·The American Journal of Physiology·H P HaagsmanJ A Clements
Aug 1, 1987·The American Review of Respiratory Disease·J R Wright, J A Clements
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Sep 1, 1995·IEEE Transactions on Bio-medical Engineering·T F Schuessler, J H Bates
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A VeldhuizenJ F Lewis
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·A GüntherW Seeger
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·D S StrayerB Robertson
Jan 1, 1996·The American Journal of Physiology·R A VeldhuizenJ F Lewis
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·T R KorfhagenJ A Whitsett
Dec 1, 1996·The Biochemical Journal·E PutmanH P Haagsman
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Sep 8, 1998·Biology of the Neonate·R G Spragg
Nov 14, 1998·Biochimica Et Biophysica Acta·J Goerke
Nov 14, 1998·Biochimica Et Biophysica Acta·F X McCormack
Nov 14, 1998·Biochimica Et Biophysica Acta·T R KorfhagenJ A Whitsett
Apr 7, 1999·Lung·S AnderssonT A Merritt
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Oct 6, 2000·Clinics in Chest Medicine·R G Spragg
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M LeVineT R Korfhagen
Feb 22, 2001·Annual Review of Physiology·E Crouch, J R Wright
Feb 14, 2002·Journal of Applied Physiology·Ruud A W VeldhuizenFred Possmayer
Feb 21, 2002·The European Respiratory Journal·A M BrackenburyJ F Lewis
Dec 12, 2002·Chest·John D LangSadis Matalon
Jan 9, 2003·Annual Review of Physiology·James F Lewis, Ruud Veldhuizen
Apr 5, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Deepika JainAron B Fisher
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

❮ Previous
Next ❯

Citations

Jan 8, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zissis C ChroneosVirginia L Shepherd
Feb 5, 2010·Pediatric Pulmonology·Tatjana LazicMark R Ackermann
May 28, 2013·The International Journal of Biochemistry & Cell Biology·Fabien LecailleGilles Lalmanach
Apr 25, 2008·Biochimica Et Biophysica Acta·Yi Y ZuoFred Possmayer
Sep 25, 2014·Acta Cirúrgica Brasileira·Lucas Souto NacifLuiz Augusto Carneiro D'Albuquerque
Jun 5, 2007·Immunobiology·Grith Lykke SorensenUffe Holmskov
Mar 18, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adam A MaruscakRuud A W Veldhuizen
Jan 27, 2015·Sleep & Breathing = Schlaf & Atmung·Shao LiangYongping Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.