Physiological Evaluation for Endurance Exercise Prescription in Sickle Cell Disease

Medicine and Science in Sports and Exercise
Laurent A MessonnierL Féasson


Although strenuous exercise may expose sickle cell disease (SCD) patients to risks of vaso-occlusive crisis, evidence suggests that regular endurance exercise may be beneficial. This study aimed to test (i) the safety and usefulness of a submaximal incremental exercise in evaluating physical ability of SCD patients and identify a marker for the management of endurance exercise and (ii) the feasibility of endurance exercise sessions in SCD patients. Twenty adults with SCD (12 men and 8 women) performed a submaximal incremental exercise used to determine the first lactate threshold (LT1) and stopped as soon as blood lactate concentration ([lactate]b) reached ≥4 mmol·L. Fifteen of those patients (8 men and 7 women) also performed three 30-min endurance exercise sessions at ~2.5 mmol·L of [lactate]b on separate occasions. LT1 occurred at 47 ± 3 and 33 ± 3 W for men and women, respectively, demonstrating the extreme deconditioning and, thus, low physical ability of adult SCD patients. During endurance exercise, peripheral oxygen saturation and [lactate]b most often remained stable and within acceptable ranges. The proposed strategy of submaximal incremental exercise allowed safe determination of LT1, an important parameter of patien...Continue Reading


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Related Concepts

Anemia, Sickle Cell
Diastolic Blood Pressure
Pulse Rate
Anaerobic Threshold
Respiratory Mechanics
Exercise Tolerance
Ammonium lactate
Biological Markers
Male Population Group

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