Physiological functions of FBW7 in cancer and metabolism

Cellular Signalling
Kouhei ShimizuWenyi Wei

Abstract

FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCFFBW7 plays key roles in regulating cell cycle progression, differentiation, and stem cell maintenance largely through targeting a broad range of oncogenic substrates for proteasome-dependent degradation. The identification of an increasing number of FBW7 substrates for ubiquitination, and intensive in vitro and in vivo studies have revealed a network of signaling components controlled by FBW7 that contributes to metabolic regulation as well as its tumor suppressor role. Here we mainly focus on recent findings that highlight a critical role for FBW7 in cancer and metabolism.

Citations

Feb 1, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lan BaiHongliang Li
Mar 30, 2019·Cell Communication and Signaling : CCS·Yi QinXiaowu Xu
Sep 7, 2019·PloS One·Andreas HähleFelix Hausch
Sep 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seira HoshikawaHiroyuki Inuzuka
Jul 13, 2018·International Journal of Molecular Sciences·Ernestina M De FrancescoAnna Maria Musti
Feb 8, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aya Shiba-IshiiMasayuki Noguchi
Mar 7, 2021·International Journal of Molecular Sciences·Shasha YinWenjian Gan
Apr 4, 2021·Journal of Clinical Medicine·Frédéric SoysouvanhRobert Ballotti
Aug 28, 2021·Life·Marco BarchiPaola Grimaldi
Nov 25, 2021·Applied Biochemistry and Biotechnology·K Archana Vasuki, H Jemmy Christy

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