Physiological impact of continuous flow on end-organ function: clinical implications in the current era of left ventricular assist devices

Methodist DeBakey Cardiovascular Journal
Arvind BhimarajErick E Suarez

Abstract

The clinical era of continuous-flow left ventricular assist devices has debunked many myths about the dire need of a pulse for human existence. While this therapy has been documented to provide a clear survival benefit in end-stage heart failure patients, we are now faced with certain morbidity challenges that as of yet have no easy mechanistic physiological explanation. The effect of physiological changes on end-organ function in patients supported by continuous-flow ventricular assist devices may offer insight into some of these morbidities. We therefore present a review of current evidence documenting the impact of continuous flow on end-organ function.

References

Jun 1, 1995·The Annals of Thoracic Surgery·M J Thubrikar, F Robicsek
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Y OrimeY Sezai
Aug 16, 2000·American Journal of Physiology. Cell Physiology·X PengD A Kass
Dec 18, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E V PotapovR Hetzer
Jan 27, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel ZimpferMichael Grimm
Mar 28, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Offer AmirFrank W Smart
Jan 16, 2007·Handbook of Experimental Pharmacology·W Liedtke
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Adam R TravisSteven C Koenig
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Branislav RadovancevicO H Frazier
Oct 13, 2009·Journal of Thrombosis and Haemostasis : JTH·C BaldaufF Gräter
May 18, 2010·Interactive Cardiovascular and Thoracic Surgery·Philipp DiehlMartin Moser
Jul 5, 2011·The International Journal of Artificial Organs·Mark S SlaughterSteven C Koenig
Oct 12, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tomoko S KatoDonna Mancini
Dec 22, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Andres F OsorioWilliam M DeCampli
Dec 24, 2011·Journal of the American College of Cardiology·Tal HasinSudhir S Kushwaha
Dec 31, 2011·Stroke; a Journal of Cerebral Circulation·Tomoko S KatoDonna M Mancini
Jul 24, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ashim AggarwalGeetha Bhat
Sep 22, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Evgenij V PotapovThomas Krabatsch
Nov 6, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Masahiro OnoCharles W Hogue
Mar 5, 2013·Journal of Neurosurgery·Thomas J WilsonJeffrey J Fletcher
Aug 24, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ana M SeguraO H Frazier
Oct 1, 2013·The Annals of Thoracic Surgery·Brent C LampertJeffrey J Teuteberg
Nov 12, 2013·Circulation. Heart Failure·Meredith A BriscoJeffrey M Testani
Dec 3, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John T ReulO H Frazier
Dec 5, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Egemen TuzunTheresa W Fossum
Dec 10, 2013·Journal of the American College of Cardiology·Andrew J BoyleUNKNOWN HeartMate II Clinical Investigators
Jan 23, 2014·Journal of Vascular Surgery·J Westley OhmanPatrick J Geraghty
Feb 15, 2014·Blood Purification·Huijuan MaoClaudio Ronco
Mar 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Angelo NascimbeneO H Frazier
May 27, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young

❮ Previous
Next ❯

Citations

Nov 3, 2015·Expert Review of Cardiovascular Therapy·Erin M SchumerMark S Slaughter
Oct 11, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Raheel RizwanDavid L Morales
Nov 14, 2018·Expert Review of Cardiovascular Therapy·Kevin GoodwinRochus Voeller
Jun 22, 2018·PM & R : the Journal of Injury, Function, and Rehabilitation·Sarah M EickmeyerLeslie Rydberg
May 22, 2019·Journal of Cardiac Surgery·Athanasios TsiourisPanayiotis D Mitsias
Mar 12, 2021·Current Neurology and Neuroscience Reports·Aaron ShoskesSung-Min Cho
May 8, 2021·The International Journal of Artificial Organs·Sam EmmanuelChristopher Hayward

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Keith M SwetzSoon J Park
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Branislav RadovancevicO Howard Frazier
© 2021 Meta ULC. All rights reserved