Physiological impact of extracellular vesicles on female reproductive system; highlights to possible restorative effects on female age-related fertility

BioFactors
Halimeh MobarakMahdi Mahdipour

Abstract

An alternative mechanism of cell-to-cell communication via extracellular vesicles (EVs) has recently raised increasing attention. EVs are spherical structures comprising exosomes and microvesicles, capable of transferring regulatory molecules and genetic information from one cell to another. EVs act as modulators which can alter a wide spectrum of functions at the cellular level in the recipient cells, taking part in a variety of biological processes in both physiological and pathological conditions. Alteration in EVs content, notably exosomes, was reported during cellular senescence and in patients with age-related diseases. Most studies reported regulating the impacts of exosomes on fertility and pregnancy outcomes via their capability in carrying developmental signaling molecules like proteins, RNA cargos, influencing gene expressions, affecting growth, and development of embryos during aging. Alterations in the exosomal content and functions can influence the reproductive performance in human and animals as conveyors of senescence signals from outside of the cells. This review aimed to summarize evidence on the role of EVs on modulating fertility, early embryonic development, maternal-embryo crosstalk for the recognition, a...Continue Reading

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Citations

Nov 21, 2019·Current Stem Cell Research & Therapy·Shahin AhmadianMohammad Nouri
Jun 19, 2020·International Journal of Molecular Sciences·Liliana Czernek, Markus Düchler
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Yu LiuWenpei Xiang
Mar 16, 2021·Life Sciences·Halimeh MobarakMahdi Mahdipour

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