Physiological impairment in mild COPD

Respirology : Official Journal of the Asian Pacific Society of Respirology
Denis E O'DonnellAmany F Elbehairy

Abstract

Chronic obstructive pulmonary disease (COPD) is a common and often progressive inflammatory disease of the airways, alveoli and microvasculature that is both preventable and treatable. It is well established that smokers with mild airway obstruction, as spirometrically defined, represent the vast majority of patients with COPD, yet this population has not been extensively studied. An insidious preclinical course means that mild COPD is both underdiagnosed and undertreated. In this context, recent studies have confirmed that even patients with mild COPD can have extensive physiological impairment, which contributes to poor perceived health status compared with non-smoking healthy controls. This review describes the heterogeneous pathophysiology that can exist in COPD patients with only mild airway obstruction on spirometry. It exposes the compensatory adaptations that develop in such patients to ensure that the respiratory system fulfils its primary task of maintaining adequate pulmonary gas exchange for the prevailing metabolic demand. It demonstrates that adaptations such as increased inspiratory neural drive to the diaphragm due to combined effects of increased mechanical loading and chemostimulation underscore the increased ...Continue Reading

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Mar 28, 2017·Annals of the American Thoracic Society·J Alberto NederUNKNOWN Canadian Respiratory Research Network
Jan 25, 2018·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Frederico Leon Arrabal FernandesFernando Luiz Cavalcanti Lundgren
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Mar 28, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Don D Sin, Gregory G King
Sep 2, 2020·Journal of Clinical Medicine·Prem BhattaraiSukhwinder Singh Sohal
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Feb 11, 2021·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Danilo Cortozi BertonMarcelo Basso Gazzana
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·J Alberto NederDenis E O'Donnell

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