Physiological Mechanisms of Airway Hyperresponsiveness in Obese Asthma

American Journal of Respiratory Cell and Molecular Biology
Jason H T Bates

Abstract

Obesity affects the incidence and severity of asthma in at least two major phenotypes: an early-onset allergic (EOA) form that is complicated by obesity and a late-onset nonallergic (LONA) form that occurs only in the setting of obesity. Both groups exhibit airway hyperresponsiveness to methacholine challenge but exhibit differential effects of weight loss. Measurements of lung function in patients with LONA obese asthma suggest that this group of individuals may simply be those unlucky enough to have airways that are more compliant than average, and that this leads to airway hyperresponsiveness at the reduced lung volumes caused by excess adipose tissue around the chest wall. In contrast, the frequent exacerbations in those with EOA obese asthma can potentially be explained by episodic inflammatory thickening of the airway wall synergizing with obesity-induced reductions in lung volume. These testable hypotheses are based on the strong likelihood that LONA and EOA obese asthma are distinct diseases. Both, however, may benefit from targeted therapeutics that impose elevations in lung volume.

References

Sep 1, 1990·Journal of Applied Physiology·J H Bates, J G Martin
Jan 1, 1997·Journal of Applied Physiology·M LeiD H Eidelman
Jun 10, 2003·Journal of Applied Physiology·Brent E McParlandPeter D Pare
Aug 12, 2003·Journal of Applied Physiology·Vito Brusasco, Riccardo Pellegrino
Dec 9, 2003·Journal of Applied Physiology·Scott WagersJason H T Bates
Feb 10, 2004·Journal of Applied Physiology·Lauren D BlackKenneth R Lutchen
Oct 22, 2005·Journal of Applied Physiology·Jason H T BatesCharles G Irvin
Mar 2, 2006·The European Respiratory Journal·M Peters-GoldenJ M Edelman
Aug 12, 2006·Journal of Applied Physiology·Derek A Affonce, Kenneth R Lutchen
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Oct 21, 2006·Journal of Applied Physiology·Stephanie A Shore
Jan 6, 2007·Journal of Applied Physiology·Jason H T Bates, Anne-Marie Lauzon
Jan 20, 2007·American Journal of Respiratory and Critical Care Medicine·David A Beuther, E Rand Sutherland
Aug 10, 2007·Respiratory Medicine·Louis-Philippe Boulet, Edmee Franssen
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Peter D ParéChun Y Seow
Sep 22, 2007·Journal of Applied Physiology·Jason H T BatesLennart K A Lundblad
Oct 24, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C M SalomeG G King
Oct 27, 2007·American Journal of Respiratory and Critical Care Medicine·Jason H T BatesCharles G Irvin
Jan 29, 2008·Obesity·Michael Vortmann, Mark D Eisner
Apr 19, 2008·Journal of Applied Physiology·Ana CojocaruJason H T Bates
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·E Rand SutherlandDonald Y M Leung
Sep 9, 2008·The Journal of Allergy and Clinical Immunology·David M MosenCarlos A Camargo
Apr 24, 2009·Proceedings of the American Thoracic Society·Charles G Irvin, Jason H T Bates
Jun 30, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason H T BatesCharles G Irvin
Sep 12, 2009·Journal of Applied Physiology·Stephanie A ShoreRichard A Johnston
Oct 3, 2009·Journal of Applied Physiology·Gilman B AllenJason H T Bates
Jan 27, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Carlos A CamargoThomas J Ferro
May 4, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mohammad Afzal KhanLuke J Janssen
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Erick FornoUNKNOWN Childhood Asthma Management Program Research Group
May 25, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Karen H YehE R McFadden
Jun 1, 2011·The Journal of Allergy and Clinical Immunology·Fernando HolguinSally E Wenzel
Jul 26, 2011·The Journal of Allergy and Clinical Immunology·Anne E DixonCharles G Irvin
Aug 9, 2011·The Journal of Allergy and Clinical Immunology·Kenneth B QuintoSandra C Christiansen
Oct 21, 2011·Critical Reviews in Biomedical Engineering·Jason H T Bates, Geoffrey N Maksym
Mar 10, 2012·American Journal of Respiratory and Critical Care Medicine·Alan L JamesFrancis H Green
Apr 4, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William J Anderson, Brian J Lipworth
May 19, 2012·PloS One·E Rand SutherlandUNKNOWN Asthma Clinical Research Network
Dec 13, 2012·Frontiers in Physiology·John D Brannan, M Diane Lougheed
Apr 27, 2013·Current Allergy and Asthma Reports·Shyamala PradeepanAnne E Dixon
Dec 10, 2013·The Journal of Allergy and Clinical Immunology·Michael SchatzTmirah Haselkorn
May 14, 2014·American Journal of Respiratory and Critical Care Medicine·Ali Al-AlwanAnne E Dixon
Aug 21, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·David G ChapmanAnne E Dixon
Oct 25, 2014·Journal of Applied Physiology·Jason H T Bates, Anne E Dixon

❮ Previous
Next ❯

Citations

May 11, 2016·American Journal of Respiratory Cell and Molecular Biology·Benjamin T Suratt
Nov 6, 2018·Current Opinion in Pulmonary Medicine·Jon GraceNjira Lucia Lugogo
Jul 3, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Torsten SchröderYves Laumonnier
Jul 14, 2016·Multidisciplinary Respiratory Medicine·Thiago Thomaz MafortAgnaldo José Lopes
Jul 10, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Toufic A Chaaban
Sep 16, 2020·Pediatric Pulmonology·Brian P O'SullivanUNKNOWN IDeA States Pediatric Clinical Trials Network
Jan 21, 2021·Journal of Physiological Anthropology·Rodrigo Muñoz-CofréMariano Del Sol
Dec 11, 2020·Respiratory Physiology & Neurobiology·Daniel P WilhiteTony G Babb
Dec 23, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Madeleine M MankMatthew E Poynter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

Expert Review of Respiratory Medicine
Anne E Dixon
Respirology : Official Journal of the Asian Pacific Society of Respirology
David G ChapmanAnne E Dixon
The American Journal of Medicine
A J Woolcock, J Read
Journal of Pharmacological and Toxicological Methods
S D KeirC P Page
© 2022 Meta ULC. All rights reserved