Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species

Toxicology and Applied Pharmacology
F G KingL S Birnbaum

Abstract

A flow-limited physiological model was developed to describe the time course of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in the blood and tissues of rats, mice, and monkeys. The liver showed the greatest tendency to concentrate the material with tissue-to-blood distribution coefficients ranging from 30 in the monkey to 130 in the mouse. TCDF was also concentrated in the fat with tissue-to-blood distribution coefficients between 25 and 40 in all species. TCDF was eliminated by metabolism followed by excretion primarily to the feces. Urinary excretion was a minor route of elimination in all species. Metabolism was modeled as a linear process occurring in the liver. Intrinsic metabolic clearances ranged from 0.45 ml/min/kg in the monkey to 2.8 ml/min/kg in one species of mice. Fecal excretion of TCDF-derived radioactivity can be simulated with a series of well-mixed compartments which receive input of metabolites in the bile.

References

Jan 1, 1979·Cancer Chemotherapy and Pharmacology·H S Chen, J F Gross
Jan 1, 1976·Bulletin of Environmental Contamination and Toxicology·J NagayamaY Masuda
Mar 1, 1974·Archives of Environmental Contamination and Toxicology·F T LindstromS E Rodecap
Aug 1, 1971·Journal of Pharmaceutical Sciences·K B BischoffJ A Longstreth
Jun 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·P M BungayH B Matthews
Feb 1, 1981·Toxicology and Applied Pharmacology·G M DecadH B Matthews
Sep 15, 1980·Toxicology and Applied Pharmacology·L S BirnbaumH B Matthews
Apr 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·K J Himmelstein, R J Lutz

❮ Previous
Next ❯

Citations

Oct 1, 1996·Applied Biochemistry and Biotechnology·N I LarionovaE N Gorbatova
Sep 1, 1995·Toxicology·L A Buckley
Jan 1, 1992·Comparative Biochemistry and Physiology. A, Comparative Physiology·A D HoffmanM L Gargas
Jun 9, 2001·Chemico-biological Interactions·M C Kohn, R L Melnick
Feb 1, 2003·Toxicology Letters·Melvin E Andersen
Dec 12, 2003·Journal of Toxicology and Environmental Health. Part a·P Robinan GentryHarvey J Clewell
Jun 21, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew J ZwiernikRobert A Budinsky
Feb 1, 1993·Risk Analysis : an Official Publication of the Society for Risk Analysis·M E AndersenW F Greenlee
Feb 17, 2000·Annals of the New York Academy of Sciences·L Edler
Sep 1, 1985·Environmental Health Perspectives·L S Birnbaum
Dec 1, 1994·Environmental Health Perspectives·D KrewskiM E Andersen
Oct 31, 2015·Annual Review of Pharmacology and Toxicology·Linda S Birnbaum
Dec 14, 2007·Regulatory Toxicology and Pharmacology : RTP·Rebecca A Clewell, Harvey J Clewell
Dec 1, 1987·Regulatory Toxicology and Pharmacology : RTP·J D Wilson
Feb 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·F G King, R L Dedrick
Jul 1, 1997·Toxicology and Applied Pharmacology·R Abbas, W L Hayton
Jun 25, 2002·Toxicology and Applied Pharmacology·Fred M ParhamC J Portier
Jan 1, 1994·Toxicology and Industrial Health·H J Clewell, M E Andersen
Dec 1, 1985·Toxicology and Industrial Health·H J Clewell, M E Andersen
Jul 1, 1997·Toxicology and Industrial Health·R P BrownR P Beliles
Jan 1, 1990·Critical Reviews in Toxicology·F R Johannsen
Nov 20, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom
Jun 1, 1988·Toxicology and Industrial Health·R W D'Souza, H Boxenbaum
Apr 15, 1993·Cancer Letters·M E AndersenJ R Withey
Nov 1, 1988·Toxicology and Applied Pharmacology·D J PaustenbachM E Andersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.