PMID: 19869053Aug 31, 1925

PHYSIOLOGICAL ONTOGENY : A. CHICKEN EMBRYOS. VI. DIFFERENTIATION IN THE CHICKEN EMBRYO HEART FROM THE POINT OF VIEW OF STIMULUS PRODUCTION

The Journal of Experimental Medicine
A E Cohn, Assistance of Edith L. Wile

Abstract

In these experiments we have shown that, with the technique adopted, differences in behavior are exhibited by fragments of the heart taken from different localities. The different localities behave in a more or less uniform manner. The pace-making function, for instance, is found at first throughout the cardiac tube but later it is restricted and comes to reside in a special small area at the back of the right auricle near the center. The pace-making system is able to develop a rate comparable to that shown by the whole intact heart, irrespective of the size of the fragment in which it is contained. Later, under the circumstances of the study, the ventricular structures lose the power of spontaneous contraction, and later still, the auricular ones also. It need scarcely be pointed out, however, that this loss refers only to the function of pace making. In its place, the various localities of the heart undoubtedly take on other capabilities. This is what is meant after all by differentiation. The question whether the pace-making and conduction systems reside in the remains of primitive portions of the cardiac tube in an undifferentiated form, or whether on the other hand these primitive portions develop into differentiated struc...Continue Reading

References

May 1, 1912·The Journal of Experimental Medicine·A Carrel
Aug 31, 1925·The Journal of Experimental Medicine·A E CohnAssistance of Alma Rosenthal

Citations

Feb 1, 1970·The American Journal of Cardiology·L H Van Mierop, I H Gessner
Jun 1, 1971·Comparative and General Pharmacology·P B Hollander, J T Justus
May 20, 1930·The Journal of General Physiology·E C MacdowellC G Macdowell
Jul 1, 1970·Acta Physiologica Scandinavica·G Gennser, E Nilsson
Jan 1, 1969·Circulation Research·J R CouchH E Hoff

Related Concepts

Cell Differentiation Process
Embryo
Heart
Muscle
Biomedical Tube Device
Right Auricular Appendage
Neural Tube
Conditioned Stimulus
Nodal (Pertaining to a Node)
Size

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