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Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

The Journal of Experimental Medicine

Feb 1, 1996

F J de SauvageM W Moore

PMID: 8627177

Abstract

Thrombopoietin (TPO) has recently been cloned and shown to regulate megakaryocyte and platelet production by activating the cytokine receptor c-mpl. To determine whether TPO is the only ligand for c-mpl and the major regulator of megakaryocytopoiesis, TPO deficient mice were generated b...read more

Mentioned in this Paper

Gene Dosage
Megakaryocytes
Interleukin-3
Thrombopoiesis
Bone Marrow
MPL wt Allele
Recombination, Genetic
Investigation of Megakaryocytes
Cell Differentiation Process
THPO wt Allele
58
Paper Details
References
  • References11
  • Citations204
12
  • References11
  • Citations204
12345...

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Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

The Journal of Experimental Medicine

Feb 1, 1996

F J de SauvageM W Moore

PMID: 8627177

DOI:

Abstract

Thrombopoietin (TPO) has recently been cloned and shown to regulate megakaryocyte and platelet production by activating the cytokine receptor c-mpl. To determine whether TPO is the only ligand for c-mpl and the major regulator of megakaryocytopoiesis, TPO deficient mice were generated b...read more

Mentioned in this Paper

Gene Dosage
Megakaryocytes
Interleukin-3
Thrombopoiesis
Bone Marrow
MPL wt Allele
Recombination, Genetic
Investigation of Megakaryocytes
Cell Differentiation Process
THPO wt Allele
58

Similar Papers Found In These Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Hematopoetic Stem Cells

Hematopoietic stem cells (HSCs) are the cells that give rise to blood cells of the myeloid and lymphoid lineage during hematopoiesis. HSC transplantation is an established therapeutic option for both malignant and nonmalignant indications. Here is the latest research.

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Science

Thrombocytopenia in c-mpl-deficient mice

ScienceSeptember 2, 1994
A L GurneyM W Moore
Paper Details
References
  • References11
  • Citations204
12
  • References11
  • Citations204
12345...
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