Physiological response to superantigen-adsorbing hemoperfusion in toxin-concentration-controlled septic swine

Blood Purification
Keishi MiwaToshiaki Ikeda

Abstract

Superantigens are suspected of being potent initiators of gram-positive sepsis, and new therapies for superantigen elimination are required. The effects of hemoadsorption with a superantigen-adsorbing device (SAAD) were evaluated in septic swine. Toxic shock syndrome toxin-1 (TSST-1) was infused, and blood concentration was maintained at the clinical level for 6 h. Endotoxin was then infused to induce lethal shock. All animals were hemoperfused with SAAD or a control column for 8 h and changes in pathological parameters and mortality were examined. Animals perfused with SAAD had a highly significant (p < 0.01) survival advantage compared with control groups at 24 h after initiation of the TSST-1 infusion. SAAD also suppressed the increase in the arteriovenous shunt ratio and decrease of partial arterial oxygen pressure at 6 h after TSST-1 infusion initiation. We suggest that there is a potential application of SAAD in treating superantigen-induced respiratory dysfunction and sepsis.

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Citations

Oct 29, 2008·Clinics in Chest Medicine·Steven P LaRosa, Steven M Opal
May 29, 2009·Biotechnology and Bioengineering·Hendrik AdamsTheo Verrips
Oct 28, 2011·Expert Review of Anti-infective Therapy·Eirini ChristakiSteven M Opal
Aug 7, 2013·The International Journal of Artificial Organs·Carol A HowellOleksandr P Kozynchenko

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