PMID: 9418920Jan 7, 1998Paper

Physiological roles of endothelium-derived nitric oxide in the epigastric island flaps of rabbits

Annals of Plastic Surgery
H OshimaH Ishida

Abstract

Nitric oxide (NO), identified as the mediator of endothelium-dependent relaxation of vascular smooth muscle, is known to cause a number of inflammatory conditions, especially in ischemia/reperfusion injury. This experimental study, using a rabbit epigastric island flap, was designed to investigate whether skin flap ischemia followed by reperfusion-influenced serum NO and c-GMP concentrations in the flap. In addition, we also investigated the premedicated effects of the NO synthase inhibitor and heparin on serum NO and c-GMP concentrations in skin flap ischemia/reperfusion. Serum NO concentration after 15, 30, 45, and 60 minutes of ischemia followed by reperfusion significantly increased compared with that in nonischemic control and elevated flaps. On the contrary, serum NO concentration was suppressed in L-NAME or aminoguanidine pretreated animals with ischemic group. Administration of heparin increased the serum NO concentration in elevated flaps, but suppressed it in ischemic flaps followed by reperfusion. The changes in serum c-GMP and NO concentrations were related in all of the experimental groups. These results suggest that NO may be derived from vascular endothelial cells and dilate peripheral vessels in compensation for...Continue Reading

Citations

Nov 20, 1998·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·M M al-Qattan
Nov 24, 2004·The Journal of Surgical Research·Navid AlizadehMichael S Pepper
Sep 27, 2005·Journal of the American College of Surgeons·Shelby G ToppWilliam C Lineaweaver
Oct 27, 1999·The Journal of Surgical Research·M T EgintonJ A Freischlag
Apr 11, 2001·Annals of Plastic Surgery·J E LovettJ Ochoa
May 29, 2004·Annals of Plastic Surgery·Feng ZhangWilliam C Lineaweaver
Jun 28, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·D T EfronA Barbul
Jan 21, 2003·Archives of Facial Plastic Surgery·Babak AzizzadehKeith E Blackwell
May 3, 2012·Clinical Pharmacology and Therapeutics·C OpländerC V Suschek
Apr 9, 2001·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·K NakamuraM Itoman
Jan 29, 2019·Journal of Plastic Surgery and Hand Surgery·Bin ZhaoHede Yan

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