PMID: 11314767Apr 21, 2001Paper

Physiological significance of the rate constants in compartmental analysis

Nuclear Medicine Communications
N D Charkes

Abstract

Transfer (rate) constants in compartmental analysis are generally considered solely in operational terms, and little attention has been paid to their physiological interpretation. In this study we have examined the significance of their roles in physiological terms and the implications of this interpretation. When freely diffusible tracers are introduced into the blood stream by bolus injection, the sum of the exit rate constants from the blood compartment gives the number of blood volumes turned over per unit time; when multiplied by the blood volume, this value is the cardiac output. When corrected for body weight, the product yields the cardiac index, a biological constant for large mammals. The ratio of the rate constant supplying an organ to the exit-constant sum gives fractional cardiac output, and when multiplied by the cardiac output the ratio gives organ blood flow, independent of diffusibility. For freely diffusible tracers, organ blood flow can be calculated directly from the product of the organ rate constant and blood volume. At equilibrium and at equal concentration, the ratio of rate constants between adjacent compartments gives their relative volumes; this interpretation is fundamental when partitioning compartm...Continue Reading

References

Dec 1, 1979·European Journal of Nuclear Medicine·T LahtinenE M Alhava
Jan 1, 1979·The American Journal of Physiology·T Akiyama, H A Fozzard
Sep 1, 1975·The American Journal of Physiology·R G TancrediJ B Bassingthwaighte
Sep 8, 1965·Annals of the New York Academy of Sciences·J L PattersonD R Waldo
Dec 1, 1968·Journal of Applied Physiology·S KaiharaH N Wagner
Jun 1, 1981·Circulation·H R SchelbertD E Kuhl
May 1, 1997·Annals of Biomedical Engineering·K H Norwich
Oct 21, 1998·Annals of Biomedical Engineering·D A Beard, J B Bassingthwaighte
Aug 19, 1999·Nuclear Medicine Communications·N D Charkes, J A Siegel

❮ Previous
Next ❯

Citations

Mar 17, 2020·The British Journal of Nutrition·Alexandre R LoboCélia Colli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
S C GeorgeA L Babb
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
G D LoizouM W Anders
British Journal of Anaesthesia
R A SaraivaW W Mapleson
International Archives of Occupational and Environmental Health
M X PetreasS M Rappaport
© 2021 Meta ULC. All rights reserved