Physiological, Tumor, and Metastatic Niches: Opportunities and Challenges for Targeting the Tumor Microenvironment

Critical Reviews in Oncogenesis
Meera MurgaiRosandra Kaplan

Abstract

The primary tumor niche and the related but distinct premetastatic/metastatic niche comprise a number of essential players, including immune cells, stromal cells, and extracellular matrix. The cross-talk between these components is key to tumor progression. Many of these cell types and signaling pathways in the tumor microenvironment also are found in physiological and stem cell niches, such as the bone marrow, colonic crypt, and skin bulge. Here they play tightly regulated roles in wound healing and tissue homeostasis. Understanding the similarities and differences between these distinct niches may better inform our ability to therapeutically target the tumor microenvironment. In this review we discuss a number of tumor and metastatic niche components as they relate to stem cell niches and highlight potential therapeutic strategies in pediatric cancers.

Citations

Jul 21, 2017·International Journal of Molecular Sciences·Emmanuelle BergerAlain Géloën
Aug 5, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunsuke TsuzukiYusuke Shiozawa
Mar 27, 2020·Frontiers in Oncology·Avishek BhuniyaRathindranath Baral
May 8, 2021·Cancer Metastasis Reviews·Sugandha Saxena, Rakesh K Singh

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