Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats

Journal of Neurophysiology
P R Patrylo, F E Dudek

Abstract

In humans with temporal lobe epilepsy and kainate-treated rats, the mossy fibers of the dentate granule cells send collateral axons into the inner molecular layer. Prior investigations on kainate-treated rats demonstrated that abnormal hilar-evoked events can occasionally be observed in slices with mossy fiber sprouting when gamma-aminobutyric acid-A (GABAA)-mediated inhibition is blocked with bicuculline. However, these abnormalities were observed infrequently, and it was unknown whether these rats were epileptic. Wuarin and Dudek reported that in slices from kainate-induced epileptic rats (3-13 mo after treatment), hilar stimulation evoked abnormal events in most slices with mossy fiber sprouting exposed simultaneously to bicuculline and elevated extracellular potassium concentration [K+]o. Using the same rats, extracellular recordings were obtained from granule cells in hippocampal slices to determine whether 1) hilar stimulation could evoke abnormal events in slices with sprouting in normal artificial cerebrospinal fluid (ACSF), 2) adding only bicuculline could unmask hilar-evoked abnormalities and glutamate-receptor antagonists could block these events, and 3) increasing only [K+]o could unmask these abnormalities. In norm...Continue Reading

References

Jan 1, 1979·Annual Review of Physiology·G G Somjen
May 19, 1978·Brain Research·P A Schwartzkroin, D A Prince
Nov 1, 1985·Journal of Neurophysiology·P A RuteckiD Johnston
Sep 1, 1989·Annals of Neurology·T SutulaL Ramirez
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Apr 1, 1986·The Journal of Physiology·R Miles, R K Wong
Jan 1, 1988·Journal of Neurophysiology·S F Traynelis, R Dingledine
Jul 1, 1987·The Journal of Physiology·R Miles, R K Wong
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Feb 1, 1984·Journal of Neurophysiology·R A Fricke, D A Prince
May 14, 1982·Science·R D Traub, R K Wong
Dec 1, 1982·Canadian Journal of Physiology and Pharmacology·K KrnjevićR J Reiffenstein
Apr 7, 1980·Brain Research·C BenningerD A Prince
Jan 1, 1994·Progress in Neurobiology·G Sperk
Apr 1, 1993·Journal of Neurophysiology·D A Prince, G F Tseng
Mar 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·F E Dudek, M Spitz

❮ Previous
Next ❯

Citations

May 5, 1999·Current Opinion in Neurology·S B Bausch, J O McNamara
Nov 28, 2002·The Journal of Comparative Neurology·Helen E ScharfmanJeffrey H Goodman
Mar 6, 2003·The Journal of Comparative Neurology·José E CavazosThomas P Sutula
Jan 12, 2001·Journal of Neurophysiology·B N Smith, F E Dudek
Jul 13, 1999·Journal of Neurophysiology·P R PatryloA Williamson
May 20, 2003·The European Journal of Neuroscience·Akiva S CohenDouglas A Coulter
Aug 17, 2004·Epilepsy Currents·F Edward Dudek
Jul 5, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yuji Ikegaya
Aug 30, 2008·The Journal of Physiology·Caroline Le DuigouRichard Miles
May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·William D HendricksEric Schnell
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J DeLorenzoS Sombati
Nov 9, 2000·Journal of Neurophysiology·J L HardisonJ V Nadler
Feb 26, 1999·Journal of Neurophysiology·P S Buckmaster, F E Dudek
Jul 7, 2009·Nature Reviews. Neurology·Sanjay N Rakhade, Frances E Jensen
Mar 15, 2001·Journal of Neurophysiology·J P Wuarin, F E Dudek
Feb 26, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Markus M LindroosIrma E Holopainen
Feb 28, 2006·Epilepsia·Peter R PatryloScott Cranick
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sarah Feldt MuldoonRosa Cossart

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.