Physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging

Acta Radiologica
Guohua ShenAnren Kuang

Abstract

18F-fluorodeoxyglucose *Equal contributors. positron emission tomography/computed tomography (18F-FDG PET/CT) has proven to be a valuable imaging modality for the assessment of bone marrow condition. To investigate the physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging, and correlate the appearance with clinical factors including gender, body mass index, and age. A total of 64 healthy individuals underwent PET/CT scan, and for each vertebral body, the mean and maximum standardized uptake value (SUVmean and SUVmax) were determined in the central slice of vertebral body on the transversal fused PET/CT image. For each individual, the FDG uptake of the four regions was obtained by averaging the SUVmean and SUVmax of the vertebrae in individual regions. The FDG uptake from thoracic to sacral vertebrae showed an upward trend first, then a downward trend, while that of cervical vertebrae was relatively stable. The SUVmax and SUVmean values of bone marrow in the old group (age ≥ 50 years) were significantly lower than those in the young group (age < 50 years) in all regions of the spine ( P < 0.05). FDG uptake of the whole spine showed significant negative correlation with age, and the stro...Continue Reading

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Citations

Jun 3, 2020·Cancers·Charles MesguichElif Hindié
Dec 12, 2020·Seminars in Musculoskeletal Radiology·Johan L BloemIris M Noebauer-Huhmann

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Methods Mentioned

BETA
biopsy

Software Mentioned

Syntegra
SPSS

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