PMID: 9430792Feb 7, 1998Paper

Physiological variations in blood glucose concentration affect oesophageal motility and sensation in normal subjects

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
G E BoeckxstaensR H Holloway

Abstract

A marked elevation in the blood glucose concentration (approximately 15 mmol L-1) slows oesophageal peristalsis. Recent studies indicate that changes in blood glucose within the normal postprandial range affect gastric motility and emptying. The aim of this study was to investigate whether such alterations in blood glucose also affect oesophageal motility. In eight healthy subjects oesophageal motility and sensation to balloon distension were measured on two separate days while blood glucose concentrations were stabilized with an insulin-glucose clamp at 4 mmol L-1 and 8 mmol L-1. Peristaltic velocity in the proximal oesophagus and over the oesophagus as a whole was faster at a plasma glucose concentration of 8 mmol L-1 compared with those at 4 mmol L-1 (proximal 3.3 +/- 0.3 cm s-1 vs 2.6 +/- 0.2 cm s-1, P < 0.05, total 3.1 +/- 0.2 cm s-1 vs 2.7 +/- 0.2 cm s-1, P < 0.005) but there were no differences in wave amplitude or duration, or basal lower oesophageal sphincter pressure (LOSP). The threshold for initial perception of oesophageal distension was lower at a plasma glucose of 8 mmol L-1 (2.9 +/- 0.5 mL vs 4.9 +/- 1.0 mL, P < 0.05). physiological variations in plasma glucose concentration influence oesophageal motility and se...Continue Reading

Citations

Dec 2, 2004·Critical Care Nursing Clinics of North America·Susan R Roberts, Bahar Hamedani
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Tsutomu NishidaMasatsugu Hori
Apr 10, 2010·World Journal of Gastroenterology : WJG·Jeong Hwan KimJeeyoung Oh
Aug 22, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J F AscasoA Benages
Sep 4, 2010·European Journal of Pain : EJP·Jens Brøndum FrøkjærAsbjørn Mohr Drewes
Jul 14, 2010·European Journal of Clinical Investigation·Jens B FrøkjaerAsbjørn M Drewes
Oct 28, 2016·Annals of the New York Academy of Sciences·Jingbo Zhao, Hans Gregersen
Jun 3, 1999·European Journal of Clinical Investigation·A RussoW M Sun
Feb 20, 2003·The American Journal of Gastroenterology·Nicholas J Talley
Apr 2, 2002·The American Journal of Gastroenterology·Peter BytzerMichael Horowitz
Nov 24, 1999·The American Journal of Gastroenterology·R H HollowayA Russo
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Jens B FrøkjaerPeter Funch-Jensen
Nov 1, 1998·Journal of Gastroenterology and Hepatology·Michael HorowitzRobert Fraser
Apr 8, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qing ZhangRichard H Holloway
Mar 10, 1999·The American Journal of Physiology·M A VerhagenM Horowitz
Mar 10, 1999·The American Journal of Physiology·T LingenfelserM Horowitz

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