Physiologically based pharmacokinetic (PB-PK) models in the study of the disposition and biological effects of xenobiotics and drugs

Toxicology Letters
M E Andersen

Abstract

Physiologically based pharmacokinetic (PB-PK) models have been used to study the mechanisms of disposition of drugs and xenobiotics for almost 70 years. Their widespread application in toxicology began 15 years ago with models for polychlorinated biphenyls and other persistent lipophilic compounds. Quantitative applications of PB-PK moels in carcinogen risk assessment date to the development of a number of PB-PK models for dichloromethane in the mid 1980s. The expanding use of these models is primarily related to their ability to make more accurate predictions of target tissue dose for different exposure situations in different animal species, including humans, and to evaluate quantitatively the mechanisms of disposition of chemicals within the body. This paper discusses contemporary uses of PB-PK modeling in the context of risk assessment with xenobiotics and of safety assessment with drugs.

References

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Citations

Oct 20, 2006·SAR and QSAR in Environmental Research·S C BasakB D Gute
Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T LavéM Reddy
Aug 1, 1995·Risk Analysis : an Official Publication of the Society for Risk Analysis·M E AndersenK Krishnan
Dec 6, 2018·Trials·Angelos G KoliasUNKNOWN British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Oct 1, 2005·Alternatives to Laboratory Animals : ATLA·Sandra CoeckeJohannes J M van de Sandt
Sep 24, 2005·Annals of the New York Academy of Sciences·William SlikkerDonald R Mattison

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