Physiology and biochemistry of streptomycetes. X. Biological degradation of paromomycin and alkaline phosphatase activity depending on antibiotic production by Streptomyces albus var. metamycinus nov. var

Zeitschrift für allgemeine Mikrobiologie
B LiebermannG Reuter


After adding 14C-paromomycin to the fermentation broth we observed a varying course of decomposition of the antibiotic, which is dependent on the intensity of paromomycin biosynthesis running simultaneously. At a reduced rate of antibiotic biosynthesis, the activity of alkaline phosphatase is lower than with an increased rate of production. This applies for mycelium as well as for broth.

Related Concepts

Alkaline Phosphatase
Glucose, (beta-D)-Isomer
Paromomycin Sulfate (2: 5)

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