Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

The Journal of Physiology
Norman R SaundersMark D Habgood

Abstract

Properties of the local internal environment of the adult brain are tightly controlled providing a stable milieu essential for its normal function. The mechanisms involved in this complex control are structural, molecular and physiological (influx and efflux transporters) frequently referred to as the 'blood-brain barrier'. These mechanisms include regulation of ion levels in brain interstitial fluid essential for normal neuronal function, supply of nutrients, removal of metabolic products, and prevention of entry or elimination of toxic agents. A key feature is cerebrospinal fluid secretion and turnover. This is much less during development, allowing greater accumulation of permeating molecules. The overall effect of these mechanisms is to tightly control the exchange of molecules into and out of the brain. This review presents experimental evidence currently available on the status of these mechanisms in developing brain. It has been frequently stated for over nearly a century that the blood-brain barrier is not present or at least is functionally deficient in the embryo, fetus and newborn. We suggest the alternative hypothesis that the barrier mechanisms in developing brain are likely to be appropriately matched to each stag...Continue Reading

References

Nov 14, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K Mollgård, N R Saunders
Jan 1, 1977·Experimental Eye Research·N R Saunders
Jul 1, 1979·The Journal of Physiology·K M DziegielewskaN R Saunders
May 1, 1977·Developmental Biology·M E Desmond, A G Jacobson
Aug 1, 1975·Journal of Neurocytology·K Mollgøard, N R Saunders
Oct 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M van de VenterW Oelofsen
Jul 1, 1991·Experimental Physiology·J M BissonnetteC R Chao
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K M DziegielewskaN R Saunders
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K M DziegielewskaC H Tyndale-Biscoe
Feb 1, 1985·Brain Research·G FossanN R Saunders
Aug 1, 1985·Developmental Medicine and Child Neurology·M Adinolfi
Jan 5, 1972·Nature: New Biology·E Frömter, J Diamond
Apr 1, 1974·The Journal of Physiology·C A EvansM B Segal
Dec 1, 1972·The Journal of Physiology·M W BradburyN R Saunders
Apr 1, 1973·The American Journal of Physiology·W H Oldendorf
Mar 1, 1973·Zentralblatt für Veterinärmedizin. Reihe C: Anatomie, Histologie, Embryologie·H E Evans, W O Sack
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Jan 1, 1970·The Journal of Comparative Neurology·D W Caley, D S Maxwell
May 1, 1970·The Journal of Physiology·L Z Bito, R E Myers
Mar 1, 1969·The Journal of Cell Biology·M W Brightman, T S Reese
May 1, 1969·The Journal of Physiology·D K Anderson, R L Hazelwood
Mar 1, 1980·The Journal of Physiology·K M DziegielewskaS Wilkinson
Mar 1, 1980·The Journal of Physiology·K M DziegielewskaN R Saunders
Apr 15, 1981·Developmental Biology·K M DziegielewskaN R Saunders
Jan 1, 1982·Developmental Neuroscience·M E CavanaghN R Saunders
Jan 1, 1983·Anatomy and Embryology·M L ReynoldsN R Saunders
Apr 1, 1982·Equine Veterinary Journal·P D RossdaleL B Jeffcott
Sep 1, 1981·International Journal of Biometeorology·K Deswal, I S Chohan

❮ Previous
Next ❯

Citations

Jun 19, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Max I BogoradPeter C Searson
Jun 5, 2019·International Journal of Molecular Sciences·Fiona O'BrienCatherine Tuleu
Jan 18, 2020·Neurology. Neuroimmunology and Neuroinflammation·Bastien JoubertJosep Dalmau
May 18, 2020·Journal of Neuropathology and Experimental Neurology·Conrad E JohansonEsteban M Rodríguez
Apr 27, 2020·Prenatal Diagnosis·Norman R Saunders, Katarzyna M Dziegielewska
May 28, 2020·Molecular Psychiatry·Jessica MalcolmPhedias Diamandis
May 28, 2019·Nature Reviews. Endocrinology·William A Banks
Feb 11, 2020·Frontiers in Neuroscience·Alexander H BellAtul Malhotra
Dec 1, 2018·The Journal of Physiology·L BennetA J Gunn
Jun 6, 2019·Brain Structure & Function·Daniela López-EspíndolaAna Guadaño-Ferraz
Jul 11, 2020·Science·Violeta Silva-Vargas, Fiona Doetsch
Oct 18, 2020·Pharmaceutics·Mark A BryniarskiMarilyn E Morris
Feb 13, 2020·Developmental Cell·Ryann M Fame, Maria K Lehtinen
Nov 27, 2020·Frontiers in Immunology·Scott R BarnumTheresa N Schein
Apr 19, 2020·Seminars in Fetal & Neonatal Medicine·Vivien Yap, Jeffrey M Perlman
Mar 16, 2021·Radiology Case Reports·Otto Gonzalez-PardoCarlos Roa
May 6, 2021·Physiological Reviews·Martin Kaag RasmussenMaiken Nedergaard
Jul 28, 2021·Trends in Neurosciences·Jin CuiMaria K Lehtinen
Aug 5, 2020·Biochimica Et Biophysica Acta. Biomembranes·Ingrid KratzerHelen Stolp

❮ Previous
Next ❯

Methods Mentioned

BETA
proximity ligation assay
transmission electron microscopy
Assay
transgenic
electron microscopy

Software Mentioned

Duolink©

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Blood-Brain Barrier Transport in Neurodegeneration

The blood brain barrier is important for regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the blood brain barrier can be essential for regulating drug movement and dysregulation of these processes may play a role in neurodegeneration. This feed follows the latest research on this topic.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.