Physiology and morphology of substantia gelatinosa neurons intracellularly stained with horseradish peroxidase

The Journal of Comparative Neurology
G J BennettR Dubner

Abstract

Neurons in Rexed's layer II were physiologically characterized with natural and electrical stimuli applied to their cutaneous receptive fields. The neurons were then intracellularly stained with horseradish peroxidase. Three general patterns of physiological responses were found. Nociceptive specific neurons did not respond to gentle mechanical stimulation. Most responded exclusively to tissue-damaging stimuli. Some also responded to moderately heavy pressure, but these responded to noxious stimuli with an increased discharge frequency. Wide dynamic range neurons responded to both gentle mechanical stimulation and to tissue-damaging stimulation. Low-threshold mechanoreceptive neurons responded only to gentle mechanical stimulation. Some of the low-threshold mechanoreceptive neurons were innervated by primary afferents with unmyelinated axons. Excepting those low-threshold mechanoreceptive neurons with input from unmyelinated afferents, the patterns of primary afferents innervation of layer II neurons were similar to the patterns of innervation that have been found for neurons in layers I and IV-V. All but 2 of the 22 neurons that we found were recognized as being of two general morphological types. Stalked cells had their perik...Continue Reading

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Citations

Sep 22, 2000·Peptides·T D MoranP A Smith
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T J Grudt, J T Williams
Jan 1, 1989·Annals of the New York Academy of Sciences·S R WhiteD A Jackson
Nov 13, 2009·Journal of Neurophysiology·Kwan Yeop LeeJin Mo Chung
Aug 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simona NeumannAllan I Basbaum
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·A I Basbaum

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