Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine

The American Journal of Physiology
B A Jones, G J Gores

Abstract

Cell death of gastrointestinal epithelial cells occurs by a process referred to as apoptosis. In this review, we succinctly define apoptosis and summarize the role of apoptosis in the physiology and pathophysiology of epithelial cells in the liver, pancreas, and small and large intestine. The physiological mediators regulating apoptosis in gastrointestinal epithelial cells, when known, are discussed. Selected pathophysiological consequences of excessive apoptosis and inhibition of apoptosis are used to illustrate the significance of apoptosis in disease processes. These examples demonstrate that excessive apoptosis may result in epithelial cell atrophy, injury, and dysfunction, whereas inhibition of apoptosis results in hyperplasia and promotes malignant transformation. The specific cellular mechanisms responsible for dysregulation of epithelial cell apoptosis during pathophysiological disturbances are emphasized. Potential future areas of physiological research regarding apoptosis in gastrointestinal epithelia are highlighted when appropriate.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F A OberhammerR Schulte-Hermann
Jul 2, 1992·Nature·D P Lane
Aug 9, 1991·Science·K W KinzlerD McKechnie
Jan 1, 1991·International Review of Experimental Pathology·M J Arends, A H Wyllie
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Jan 1, 1991·British Journal of Cancer·R K RossB E Henderson
Apr 1, 1990·Immunology Today·D J McConkeyM Jondal
Jun 15, 1990·Annals of Internal Medicine·G L BirdR S Williams
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A BarnardH L Moses
Aug 1, 1986·The Surgical Clinics of North America·R G Martin
Sep 1, 1971·The Journal of Pathology·J F Kerr
Sep 1, 1984·Southern Medical Journal·H L LawsJ S Aldrete
Nov 17, 1995·Science·T S GriffithT A Ferguson
Dec 1, 1994·Experimental Cell Research·R NiS Nagata
Jun 1, 1995·Seminars in Cell Biology·M S Rao, J K Reddy
Jun 1, 1995·Archives of Histology and Cytology·T ShibaharaY Uchiyama
Nov 1, 1995·The Journal of Experimental Medicine·P R GalleL Runkel
Oct 1, 1995·The Surgical Clinics of North America·J A LumadueR H Hruban
Aug 26, 1993·Nature·J OgasawaraS Nagata
Feb 1, 1995·Trends in Biochemical Sciences·Y A Hannun, L M Obeid
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·A HagueC Paraskeva
Jan 1, 1994·International Journal of Radiation Biology·C S PottenA Faranda
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·B Grasl-KrauppR Schulte-Hermann
Oct 28, 1994·Biochemical and Biophysical Research Communications·E MitaT Kamada
Dec 1, 1994·The Journal of Clinical Investigation·T PatelG J Gores
Apr 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·S KishimotoT Sugiyama
Mar 11, 1994·Cell·D L VauxA Strasser

❮ Previous
Next ❯

Citations

Jan 12, 2001·Physiological Reviews·E M Brown, R J MacLeod
Aug 15, 2001·American Journal of Physiology. Cell Physiology·L LiJ Y Wang
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S FiorucciJ L Wallace
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cynthia R L WebsterM Sawkat Anwer
Sep 13, 2003·World Journal of Gastroenterology : WJG·Li WangXiang-Lin Duan
Jun 7, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria J RedlakThomas A Miller
May 6, 2005·American Journal of Physiology. Cell Physiology·Tongtong ZouJian-Ying Wang
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·L LiJ Y Wang
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A Rippe
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·N L JonesP M Sherman
Apr 13, 2004·American Journal of Physiology. Cell Physiology·Tongtong ZouJian-Ying Wang
May 15, 2001·American Journal of Physiology. Cell Physiology·R GauthierP H Vachon
Jul 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lan LiuJian-Ying Wang
Mar 30, 2006·World Journal of Gastroenterology : WJG·Laura Iris Cosen-BinkerOsvaldo Tiscornia
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carla A Martin, Asit Panja
Jan 25, 2000·American Journal of Physiology. Cell Physiology·Q DingB M Evers
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Courtney C Fleck, Hannah V Carey
Feb 7, 2021·Biology·Moses New-AaronNatalia A Osna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

American Journal of Ophthalmology
M G KrzystolikA R Frederick
The Surgical Clinics of North America
S D ChernausekM A Sperling
© 2021 Meta ULC. All rights reserved