Physiology and pathophysiology of the calcium-sensing receptor in the kidney.

American Journal of Physiology. Renal Physiology
Daniela Riccardi, E M Brown

Abstract

The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating levels of parathyroid hormone. It was molecularly identified in 1993 by Brown et al. in the laboratory of Dr. Steven Hebert with an expression cloning strategy. Subsequent studies have demonstrated that the CaSR is highly expressed in the kidney, where it is capable of integrating signals deriving from the tubular fluid and/or the interstitial plasma. Additional studies elucidating inherited and acquired mutations in the CaSR gene, the existence of activating and inactivating autoantibodies, and genetic polymorphisms of the CaSR have greatly enhanced our understanding of the role of the CaSR in mineral ion metabolism. Allosteric modulators of the CaSR are the first drugs in their class to become available for clinical use and have been shown to treat successfully hyperparathyroidism secondary to advanced renal failure. In addition, preclinical and clinical studies suggest the possibility of using such compounds in various forms of hypercalcemic hyperparathyroidism, such as primary and lithium-induced hyperparathyroidism and that occurring after renal ...Continue Reading

References

Nov 1, 1979·The American Journal of Physiology·L Barajas
Feb 1, 1977·The Journal of Pediatrics·A M SpiegelG D Aurbach
Oct 1, 1975·American Journal of Clinical Pathology·D P Rhone
Dec 1, 1992·The Journal of Clinical Endocrinology and Metabolism·S A RivkeesJ D Crawford
Feb 1, 1987·Endocrine Reviews·J C FrayA N Valentine
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·S J MarxD E Cole
Apr 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S J MarxM A Levine
Jun 1, 1984·The American Journal of Medicine·W M LawH Heath
Oct 1, 1982·Canadian Journal of Physiology and Pharmacology·G A Quamme
Mar 1, 1981·Human Pathology·U ThorgeirssonS J Marx
Jun 1, 1995·The American Journal of Physiology·M A BoimS C Hebert
Sep 1, 1995·The Journal of Clinical Endocrinology and Metabolism·K AidaT Onaya
Dec 1, 1994·The American Journal of Physiology·H AmlalM Bichara
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D RiccardiS C Hebert
Apr 15, 1993·Nature
Dec 1, 1995·The Journal of Clinical Investigation·S H PearceM P Whyte
Oct 10, 1996·The New England Journal of Medicine·S H PearceR V Thakker
Oct 1, 1996·The American Journal of Physiology·D RiccardiS C Hebert
Aug 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M KobayashiY Seino
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·E F NemethM F Balandrin
Apr 8, 1998·The American Journal of Physiology·D RiccardiS C Hebert
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·M T CollinsS J Marx

❮ Previous
Next ❯

Citations

Mar 29, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Deborah R SteinCatherine M Gordon
Nov 28, 2012·Current Urology Reports·Jianghui Hou
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Gerda E Breitwieser
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Fadil M Hannan, Rajesh V Thakker
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·R Tyler Miller
May 8, 2013·Pediatric Research·Giovanna M CrisiThomas J Campfield
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Soumaya El MoghrabiRégine Chambrey
Aug 14, 2010·Human Molecular Genetics·Conall M O'SeaghdhaAnna Köttgen
Aug 17, 2011·Current Opinion in Gastroenterology·Jessica LaRusch, David C Whitcomb
Oct 12, 2010·American Journal of Physiology. Renal Physiology·Liang FangPaul A Welling
Dec 12, 2012·American Journal of Physiology. Renal Physiology·M Cecilia Ortiz-CapisanoWilliam H Beierwaltes
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Giovanna ValentiMaria Svelto
Jun 26, 2012·Circulation Research·Aya YamamuraJason X-J Yuan
Aug 14, 2012·The Journal of Clinical Investigation·Alexandre LoupyPascal Houillier
Feb 11, 2014·Clinical Medicine & Research·Carrie E BlackAndrew C Urquhart
Nov 30, 2013·Nutrients·Ami M PatelStanley Goldfarb
Mar 17, 2012·Future Cardiology·Cristina Karohl, Paolo Raggi
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·C Gopalakrishnan NairMisha Babu
Mar 7, 2014·Canadian Journal of Physiology and Pharmacology·Fernando CasareRicardo Fernandez
Aug 7, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kristin ElfersAlexandra S Muscher-Banse
Nov 13, 2012·Annual Review of Physiology·Jianghui HouAlan S L Yu
Mar 5, 2013·Expert Opinion on Pharmacotherapy·Nicolas VerheyenAndreas Tomaschitz
Feb 24, 2015·Expert Opinion on Emerging Drugs·Mario CozzolinoAntonio Bellasi
Jul 28, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Perla C Reyes-Fernandez, James C Fleet
Jul 3, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elizabeth KuoChou-Long Huang
Jul 18, 2012·Prostaglandins & Other Lipid Mediators·Sailaja BattulaNicholas R Ferreri
Aug 2, 2013·Kidney International·Carsten A Wagner
Apr 26, 2013·Kidney International·Giovambattista CapassoJohn P Geibel
Nov 27, 2015·Biochimica Et Biophysica Acta·Samawansha TennakoonEnikö Kállay
Dec 30, 2015·Journal of Endocrinological Investigation·X-M WangX-H Wang
Aug 27, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Armando Luis Negri
Jul 21, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tanja SikjaerUNKNOWN Hypoparathyroid Study Group
Jun 27, 2012·Annals of the New York Academy of Sciences·Markus BleichNina Himmerkus
Apr 10, 2013·Journal of Veterinary Emergency and Critical Care·Joao F de Brito GalvaoDennis J Chew
Jun 2, 2011·British Journal of Pharmacology·Donald T Ward, Daniela Riccardi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.