Physiology and Predictors of Impaired Gas Exchange in Infants with Bronchopulmonary Dysplasia

American Journal of Respiratory and Critical Care Medicine
Jenny SvedenkransJ Jane Pillow

Abstract

Rationale: A sensitive outcome measure for infants with bronchopulmonary dysplasia would facilitate clinical benchmarking and enhance epidemiologic understanding, evaluation of clinical interventions, and outcome prediction.Objectives: Noninvasive assessment of pulmonary gas exchange in preterm infants with and without bronchopulmonary dysplasia to grade disease severity and to identify determinants of impaired gas exchange.Methods: This is a prospective observational study in very preterm infants. Inspired oxygen partial pressure (PiO2) was decreased stepwise to achieve oxygen saturation as measured by pulse oximetry (SpO2) that decreased from 95% to 86%. Right shift, V ⋅ a/ Q ⋅ , and right-left shunt were derived from the resulting SpO2 versus PiO2 curve and compared with current disease severity classification. Potential determinants of shift, V ⋅ a/ Q ⋅ , and shunt were identified using principal components analysis and multiple linear regression.Measurements and Main Results: A total of 219 infants with median (interquartile range) gestation of 28 weeks and 0 days (26 weeks and 0 days to 29 weeks and 0 days) had a valid study at 35 weeks and 4 days (34 weeks and 1 day to 39 weeks and 3 days) of postmenstr...Continue Reading

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Citations

Dec 10, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yonni FriedlanderGiles Santyr
Nov 16, 2019·Nature Reviews. Disease Primers·Bernard ThébaudAlan H Jobe
Oct 7, 2020·Journal of Clinical Medicine·Jenny SvedenkransKajsa Bohlin
Jan 22, 2021·European Journal of Pediatrics·Marilena SavoiaAntonio Tonutti
Apr 4, 2021·The Journal of Pediatrics·Alan H Jobe, Eduardo Bancalari
Dec 23, 2020·American Journal of Respiratory and Critical Care Medicine·Barbara LoiDaniele De Luca
Feb 9, 2021·American Journal of Respiratory and Critical Care Medicine·David G TingayAlan H Jobe
Oct 22, 2021·BMJ : British Medical Journal·Margaret GilfillanVineet Bhandari
Oct 24, 2021·The Journal of Pediatrics·Roland P NeumannSven M Schulzke
Oct 14, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard J MartinEduardo Bancalari
Jan 3, 2021·Pediatrics·Abhijeet A RakshasbhuvankarJ Jane Pillow

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Research Electronic Data Capture ( REDCap )
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