Abstract
Rationale: A sensitive outcome measure for infants with bronchopulmonary dysplasia would facilitate clinical benchmarking and enhance epidemiologic understanding, evaluation of clinical interventions, and outcome prediction.Objectives: Noninvasive assessment of pulmonary gas exchange in preterm infants with and without bronchopulmonary dysplasia to grade disease severity and to identify determinants of impaired gas exchange.Methods: This is a prospective observational study in very preterm infants. Inspired oxygen partial pressure (PiO2) was decreased stepwise to achieve oxygen saturation as measured by pulse oximetry (SpO2) that decreased from 95% to 86%. Right shift,
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, and right-left shunt were derived from the resulting SpO2 versus PiO2 curve and compared with current disease severity classification. Potential determinants of shift,
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, and shunt were identified using principal components analysis and multiple linear regression.Measurements and Main Results: A total of 219 infants with median (interquartile range) gestation of 28 weeks and 0 days (26 weeks and 0 days to 29 weeks and 0 days) had a valid study at 35 weeks and 4 days (34 weeks and 1 day to 39 weeks and 3 days) of postmenstr...Continue Reading
References
Jul 1, 1982·The Journal of Clinical Investigation·H Bard, J Prosmanne
Oct 1, 1993·British Journal of Anaesthesia·P G Roe, J G Jones
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Aug 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·H L Smith, J G Jones
Apr 2, 2003·Seminars in Neonatology : SN·Eduardo BancalariIlene R S Sosenko
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Michele C WalshAvroy Fanaroff
Nov 3, 2004·Pediatrics·Michele C WalshUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Jun 27, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·D QuineB J Stenson
Mar 3, 2007·Thorax·G L HallS M Stick
Jan 17, 2008·Chest·Steven M ResnickMary J Sharp
Oct 22, 2008·Journal of Biomedical Informatics·Paul A HarrisJose G Conde
Aug 25, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·L RoweB J Stenson
Jan 10, 2014·Journal of Clinical Monitoring and Computing·Geoffrey G LockwoodJ Gareth Jones
Aug 15, 2014·Pediatric Research·Staffan K BerglundMagnus Domellöf
Feb 26, 2015·Annals of the American Thoracic Society·Nicolas BamatHaresh Kirpalani
Mar 15, 2015·Neonatology·Theodore DassiosRobert Ross-Russell
Nov 26, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·J G JonesB J Stenson
Dec 25, 2016·Journal of Clinical Monitoring and Computing·Theodore DassiosAnne Greenough
Mar 20, 2018·The Journal of Pediatrics·Rosemary D HigginsTonse N K Raju
Citations
Dec 10, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yonni FriedlanderGiles Santyr
Nov 16, 2019·Nature Reviews. Disease Primers·Bernard ThébaudAlan H Jobe
Jan 19, 2020·Scientific Reports·Gustavo NinoMarius Linguraru
Oct 7, 2020·Journal of Clinical Medicine·Jenny SvedenkransKajsa Bohlin
Jul 21, 2020·The Lancet. Respiratory Medicine·Giovanni VentoJ Jane Pillow
Feb 13, 2021·Thorax·Benjamin StoecklinJane Pillow
Jan 22, 2021·European Journal of Pediatrics·Marilena SavoiaAntonio Tonutti
Sep 11, 2019·The Journal of Pediatrics·Theodore DassiosAnne Greenough
Apr 4, 2021·The Journal of Pediatrics·Alan H Jobe, Eduardo Bancalari
May 24, 2020·Communications Biology·Debashis SahooLawrence S Prince
Dec 23, 2020·American Journal of Respiratory and Critical Care Medicine·Barbara LoiDaniele De Luca
Feb 9, 2021·American Journal of Respiratory and Critical Care Medicine·David G TingayAlan H Jobe
Sep 22, 2021·Pediatric Pulmonology·Seung Han ShinHan-Suk Kim
Oct 22, 2021·BMJ : British Medical Journal·Margaret GilfillanVineet Bhandari
Oct 24, 2021·The Journal of Pediatrics·Roland P NeumannSven M Schulzke
Oct 14, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard J MartinEduardo Bancalari
Jan 3, 2021·Pediatrics·Abhijeet A RakshasbhuvankarJ Jane Pillow