Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative

Environmental Research
Dimosthenis SarigiannisMartin Scheringer

Abstract

Given the opportunities provided by internal dosimetry modelling in the interpretation of human biomonitoring (HBM) data, the assessment of the links between exposure to chemicals and observed HBM data can be effectively supported by PBTK modelling. This paper gives a comprehensive review of available human PBTK models for compounds selected as a priority by the European Human Biomonitoring Initiative (HBM4EU). We highlight their advantages and deficiencies and suggest steps for advanced internal dose modelling. The review of the available PBTK models highlighted the conceptual differences between older models compared to the ones developed recently, reflecting commensurate differences in research questions. Due to the lack of coordinated strategies for deriving useful biomonitoring data for toxicokinetic properties, significant problems in model parameterisation still remain; these are further increased by the lack of human toxicokinetic data due to ethics issues. Finally, questions arise as well as to the extent they are really representative of interindividual variability. QSARs for toxicokinetic properties is a complementary approach for PBTK model parameterisation, especially for data poor chemicals. This approach could be...Continue Reading

Citations

Mar 22, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Manolis TzatzarakisAristidis Tsatsakis
Jul 17, 2020·Chemical Research in Toxicology·Gabriele SabbioniBilly W Day
Jan 27, 2022·Environmental Science and Pollution Research International·Ana Socorro Rodríguez-BáezRogelio Flores-Ramírez

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