Physiology of gangliosides and the role of antiganglioside antibodies in human diseases.

Cellular & Molecular Immunology
Gianni CutilloSeppo Meri

Abstract

Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human body. They play important roles in protecting us against immune attacks, yet they can become targets for autoimmunity and act as receptors for microbes, like the influenza viruses, and toxins, such as the cholera toxin. The expression patterns of gangliosides vary in different tissues, during different life periods, as well as in different animals. Antibodies against gangliosides (AGA) can target immune attack e.g., against neuronal cells and neutralize their complement inhibitory activity. AGAs are important especially in acquired demyelinating immune-mediated neuropathies, like Guillain-Barré syndrome (GBS) and its variant, the Miller-Fisher syndrome (MFS). They can emerge in response to different microbial agents and immunological insults. Thereby, they can be involved in a variety of diseases. In addition, antibodies against GM3 were found in the sera of patients vaccinated with Pandemrix®, who developed secondary narcolepsy, strongly supporting the autoimmune etiology of the disease.

References

Jan 1, 1976·Advances in Experimental Medicine and Biology·B CeccarelliM Finesso
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Meri, M K Pangburn
Mar 31, 1988·Neuroscience Letters·J ChapmanD M Michaelson
Jan 1, 1980·Advances in Experimental Medicine and Biology·L Svennerholm
Jan 23, 1995·Behavioural Brain Research·H Rahmann
Jun 5, 1997·Nature·K Simons, E Ikonen
Jun 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·B C JacobsF G van der Meché
Jun 11, 1998·Emerging Infectious Diseases·B M AllosM J Blaser
Jul 21, 1998·Annals of the New York Academy of Sciences·J S Schneider
Oct 21, 1998·The Journal of Infectious Diseases·A P Moran, M M Prendergast
Mar 21, 2000·Seminars in Immunology·P W JanesP S Kabouridis
Sep 27, 2000·Brain : a Journal of Neurology·M MoriT Hattori
Mar 27, 2001·Journal of the Neurological Sciences·H J Willison
May 4, 2001·Brain : a Journal of Neurology·G M O'HanlonH J Willison
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sen-itiroh Hakomori Si
Jun 18, 2002·Acta Neurologica Scandinavica·M ZappiaA Quattrone
Dec 5, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Michael P PenderJudith M Greer
Feb 4, 2003·Journal of Lipid Research·Linda J Pike
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Feb 19, 1955·Nature·G BLIXI WERNER
Apr 24, 2004·Journal of the Peripheral Nervous System : JPNS·Vidmer ScaioliRenato Mantegazza
Dec 21, 2004·Arquivos de neuro-psiquiatria·José Ibiapina Siqueira NetoGisele Sampaio Silva
Apr 13, 2005·Gastroenterology·Khalafalla O Bushara
Sep 15, 2005·Cellular and Molecular Life Sciences : CMLS·I Mocchetti
Nov 8, 2005·Lancet·Richard A C Hughes, David R Cornblath
Jun 13, 2006·Journal of Neuroimmunology·Armin Alaedini, Norman Latov
Sep 20, 2006·Glycobiology·Sandro SonninoAlessandro Prinetti
Nov 23, 2006·The Medical Journal of Australia·Alan W Hampson, John S Mackenzie

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Citations

Aug 30, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Carlo CivardiClaudio Geda
Oct 10, 2020·Life Sciences·Sairaj Satarker, Madhavan Nampoothiri
Feb 16, 2021·Frontiers in Aging Neuroscience·Kathleen M Hagen, Shalina S Ousman
Dec 29, 2020·Frontiers in Immunology·Seppo Meri, Karita Haapasalo
Nov 19, 2020·Toxins·Christine Rasetti-EscargueilMichel R Popoff
Apr 22, 2021·The Biochemical Journal·J Sebastian TemmeJeffrey C Gildersleeve
May 1, 2021·International Journal of Molecular Sciences·Tetsuya Okuda
Mar 10, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Anouk SerrienPhilip Van Damme
May 30, 2021·BMC Neurology·Tao LiangZhong Luo
May 30, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Alessandro GranitoUmberto Volta
May 18, 2021·Frontiers in Pharmacology·Pei ShangHong-Liang Zhang
Jun 25, 2021·Biochemical and Biophysical Research Communications·Tetsuya OkudaKatsuya Kato
May 26, 2021·Infection and Immunity·Sean M CallahanJeremiah G Johnson
Sep 1, 2021·Biomolecules & Therapeutics·Jinwon ParkYu-Kyoung Oh
Sep 29, 2021·Acta neurologica Belgica·Woojun Kim, Jae Young An
Oct 15, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ettore CioffiMariano Serrao

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