Physiology of glucose homeostasis and insulin therapy in type 1 and type 2 diabetes

Endocrinology and Metabolism Clinics of North America
Ele Ferrannini

Abstract

An input-output schematization of plasma glucose homeostasis provides quantitative information on glucose fluxes and their control by insulin. Insulin action is dependent on the target tissue, the route of delivery, and the kinetics of insulin activation and deactivation, which are different for glucose production and disposal and are a function of insulin resistance. Under normal conditions, the closed-loop control of minute-by-minute insulin release by arterial glucose levels protects against both hyperglycemia and hypoglycemia. Open-loop insulin therapy faces the complexities of insulin pharmacokinetics and pharmacodynamics. Insulin therapy thus remains defiantly empiric.

References

Dec 1, 1989·Diabetes/metabolism Reviews·E Ferrannini, L C Groop
May 12, 1988·The New England Journal of Medicine·S O'RahillyD R Matthews
May 12, 1988·The New England Journal of Medicine·K S PolonskyE Van Cauter
Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Apr 1, 1987·Diabetes/metabolism Reviews·E Ferrannini, C Cobelli
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S PetridesG Strohmeyer
May 1, 1995·Diabetes Care·P J Lefèbvre
Apr 29, 1998·Hormone Research·K S PolonskyE Van Cauter
Oct 1, 1998·Diabetologia·A D CherringtonD K Sindelar
Jan 30, 2002·Diabetes·Niels PørksenOle Schmitz
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Patricia IozzoPirjo Nuutila
Aug 17, 2004·American Journal of Physiology. Endocrinology and Metabolism·Andrea Caumo, Livio Luzi
Sep 12, 2007·Diabetologia·E FerranniniUNKNOWN Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators
Oct 12, 2007·Physiological Reviews·Jens Juul Holst
Oct 25, 2007·Biochemical Society Transactions·A D CherringtonD S Edgerton
Aug 19, 2008·Molecular and Cellular Endocrinology·Anders Tengholm, Erik Gylfe
Feb 19, 2009·Diabetologia·E FerranniniC Gonzales-Villalpando
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Clara BoucheAllison B Goldfine
Jan 8, 2011·Diabetes & Metabolism·R Burcelin
Feb 2, 2011·The Medical Clinics of North America·Ele FerranniniPatricia Iozzo
Apr 6, 2011·Diabetologia·J C Henquin, J Rahier
Aug 26, 2011·The Journal of Clinical Investigation·Christopher J RamnananDale S Edgerton

❮ Previous
Next ❯

Citations

Jan 25, 2014·Paediatric Drugs·Faisal S Malik, Craig E Taplin
Oct 17, 2015·The Proceedings of the Nutrition Society·Romano RegazziCécile Jacovetti
Nov 15, 2018·International Journal of Environmental Research and Public Health·Suliman M Al HumayedAbdullah A Alsabaani
Mar 1, 2013·Bone Research·Francisco J A de Paula, Clifford J Rosen
Feb 27, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Hood Thabit, Roman Hovorka

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Endocrinology and Metabolism Clinics of North America
Carla A Borgoño, Bernard Zinman
Diabetes Research and Clinical Practice
Emily G MoserSatish K Garg
Endocrinology and Metabolism Clinics of North America
Marie E McDonnell, Guillermo E Umpierrez
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Viktória TerzinLászló Czakó
© 2021 Meta ULC. All rights reserved