Physiology of repetitive transcranial magnetic stimulation of the human brain

Brain Stimulation
Janna Marie HoogendamVincenzo Di Lazzaro

Abstract

During the last two decades, transcranial magnetic stimulation (TMS) has rapidly become a valuable method to investigate noninvasively the human brain. In addition, repetitive TMS (rTMS) is able to induce changes in brain activity that last after stimulation. Therefore, rTMS has therapeutic potential in patients with neurologic and psychiatric disorders. It is, however, unclear by which mechanism rTMS induces these lasting effects on the brain. The effects of rTMS are often described as LTD- or LTP-like, because the duration of these alterations seems to implicate changes in synaptic plasticity. In this review we therefore discuss, based on rTMS experiments and knowledge about synaptic plasticity, whether the physiologic basis of rTMS-effects relates to changes in synaptic plasticity. We present seven lines of evidence that strongly suggest a link between the aftereffects induced by rTMS and the induction of synaptic plasticity. It is, nevertheless, important to realize that at present it is impossible to demonstrate a direct link between rTMS on the one hand and synaptic plasticity on the other. Therefore, we provide suggestions for future, innovating research, aiming to investigate both the local effects of rTMS on the synaps...Continue Reading

References

Jun 1, 1992·Electroencephalography and Clinical Neurophysiology·J D WeissmanK R Davey
Jul 1, 1987·Behavioral and Neural Biology·M R FoyR F Thompson
Jul 1, 1987·The Journal of Physiology·C W HessN M Murray
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Apr 1, 1996·Trends in Neurosciences·W C Abraham, M F Bear
Feb 25, 2000·Brain : a Journal of Neurology·K StefanJ Classen
Aug 11, 2000·Journal of Cognitive Neuroscience·S M Fitzpatrick, D L Rothman
Oct 20, 2000·Science·M S Rioult-PedottiJ P Donoghue
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·B S Kauderer, E R Kandel
Apr 9, 2001·Experimental Brain Research·W MuellbacherM Hallett
Oct 30, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T TougeJ C Rothwell
Oct 31, 2001·Experimental Brain Research·N ModugnoJ C Rothwell
Mar 4, 2003·Journal of Neurophysiology·Alexander WoltersJoseph Classen
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wickliffe C Abraham
May 15, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G M MorrisC O'Carroll
Oct 14, 2003·The Journal of Physiology·Vincenzo RizzoJohn C Rothwell
Nov 5, 2003·Nature Reviews. Neuroscience·Robert C Malenka
Nov 15, 2003·Journal of Cognitive Neuroscience·E M RobertsonA Pascual-Leone
Dec 4, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Nicola ModugnoAlfredo Berardelli
Jan 16, 2004·Journal of Neurophysiology·Katja StefanJoseph Classen
Jan 23, 2004·Nature·Bogdan DraganskiArne May
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ulf ZiemannDiane Ruge
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yan-You HuangEric R Kandel
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Eman M KhedrJohn Rothwell
Jun 19, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alexander PeinemannHartwig Roman Siebner
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Sep 29, 2004·Neuron·Yang Dan, Mu-Ming Poo
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Noritoshi AraiYoshikazu Ugawa
Dec 6, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gary W ThickbroomFrank L Mastaglia

❮ Previous
Next ❯

Citations

May 18, 2012·Journal of Neurologic Physical Therapy : JNPT·Michelle Harris-Love
Jul 12, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Andrew M Vahabzadeh-HaghAlexander Rotenberg
Nov 11, 2011·Journal of Neurophysiology·Michael T Rubens, Theodore P Zanto
Nov 11, 2011·PloS One·Martin SchecklmannBerthold Langguth
May 3, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Craig J McAllisterStephen D Hall
Feb 27, 2014·Experimental Brain Research·Ashleigh E SmithMichael C Ridding
Dec 10, 2013·Biological Psychiatry·Christina W SlotemaIris E C Sommer
Jun 27, 2014·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Stephen E NadeauKenneth M Heilman
Jun 10, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giuseppe CosentinoFilippo Brighina
Jul 30, 2014·Journal of Psychiatric Research·Seiya MiyamotoW Wolfgang Fleischhacker
Nov 19, 2014·Neural Plasticity·Tursonjan TokayRüdiger Köhling
Sep 10, 2014·Nature Reviews. Neurology·Giovanni Di PinoVincenzo Di Lazzaro
Feb 15, 2013·Journal of Neurophysiology·Virginia CondePatrick Ragert
Oct 31, 2012·Current Opinion in Neurology·Christian Grefkes, Gereon R Fink
Apr 16, 2013·Experimental Neurology·Gregory K Bergey
May 9, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Brian D Goodwin, Christopher R Butson
Oct 4, 2011·Brain Stimulation·V Di LazzaroF Pilato
Apr 23, 2011·Experimental Gerontology·Catarina FreitasAlvaro Pascual-Leone
Apr 1, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Maria Concetta PellicciariMarta Bortoletto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.