PMID: 12405618Oct 31, 2002

Physiology of the aerodigestive system and aberrations in that system resulting in aspiration

JPEN. Journal of Parenteral and Enteral Nutrition
Mark T DeMeo, Keith Bruninga


Aspiration pneumonia remains a significant and often devastating problem in critically ill patients. It is unclear whether aspiration pneumonia occurs because of problems in the handling of oropharyngeal secretions or if the reflux of gastric contents is the major etiological factor. Additionally, the obvious breakdown of upper aerodigestive protective mechanisms in the critically ill patient population is largely unstudied. Finally, the impact and contribution of tubes, both endotracheal and nasoenteral, on aspiration pneumonia is unclear. A Medline literature search on scientific and review articles concerning the normal physiology of the aerodigestive tract and factors that compromised normal physiology was undertaken. Readings were supplemented by expert outside opinion from researchers in these fields and from the combined expertise from a multidisciplinary panel of experts assembled at a recent summit on aspiration pneumonia. Changes in the normal physiology of the aerodigestive tract are vast and varied and dependent on the response to injury, iatrogenic interventions, and the use of nasoenteral and endotracheal tubes. The effects on gastric and esophageal motility are likely dynamic and represent an ongoing but changing...Continue Reading


Apr 1, 1978·Intensive Care Medicine·N Buchanan, R D Cane
Jan 1, 1987·British Journal of Anaesthesia·D J Duthie, W S Nimmo
Apr 1, 1986·The Journal of Clinical Investigation·W G PatersonR K Goyal
Mar 1, 1995·Critical Care Medicine·V de LarminatJ M Desmonts
Mar 1, 1995·Digestive Diseases and Sciences·D L DumitrascuM Wienbeck
Nov 1, 1993·Gastroenterology·S Mayrand, N E Diamant
Jul 1, 1994·Gastroenterology·C H Malbert, C Mathis
Jan 1, 1993·Dysphagia·P J Kahrilas
Feb 1, 1993·Digestive Diseases and Sciences·J Y Kang
Jun 1, 1996·American Journal of Surgery·J J CullenD K Caropreso
Apr 1, 1997·Digestive Diseases and Sciences·J J CullenK S Ephgrave
Nov 14, 1997·Anesthesiology·D B MurphyM B Murphy
Jan 9, 1998·The American Journal of Medicine·R Shaker, I M Lang
Apr 2, 1998·Journal of Pediatric Gastroenterology and Nutrition·E SulaemanE Schmidt-Sommerfeld
Apr 4, 1998·Acta Anaesthesiologica Scandinavica·B HammasM Wattwil
Feb 3, 1999·The Medical Clinics of North America·E Domenech, J Kelly
May 11, 1999·European Journal of Anaesthesiology·N G LeveinM Wattwil
Aug 24, 1999·Acta Anaesthesiologica Scandinavica·N G LeveinM Wattwill
Nov 30, 1999·Anesthesia and Analgesia·T L LeeL C Lau
Nov 26, 1999·Digestive Diseases and Sciences·T D Lewis
Dec 28, 1999·American Journal of Surgery·K S EphgraveJ J Cullen
Jan 11, 2000·QJM : Monthly Journal of the Association of Physicians·S HadjikoutisR Eccles
Mar 16, 2000·The American Journal of Medicine·D L Broussard, S M Altschuler
Sep 16, 2000·Intensive Care Medicine·A DiveE Installé
Dec 16, 2000·Digestive Diseases and Sciences·D P HirschG E Boeckxstaens


May 25, 2010·Intensive Care Medicine·Jose Acosta-EscribanoJosé Sanchez-Payá
May 12, 2004·Heart & Lung : the Journal of Critical Care·Norma A MethenySharon J Edwards
May 12, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·E KostadimaD Sfyras
Feb 19, 2015·Acta Neurologica Scandinavica·A MuscariM Zoli
Apr 8, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catarina SilvaAntónio Guerra
Feb 3, 2007·European Journal of Clinical Nutrition·L C MatosT F Amaral
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·M Cristina G Barbosa-Silva, Aluísio J D Barros
Jun 3, 2014·Critical Care Nurse·Jan Powers
Apr 12, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Guilherme F GomesAntonio C Campos

Related Concepts

Inspiration Function
Gastrointestinal System
Digestive System Disorders
Aspiration Pneumonia

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
Douglas L Seidner
Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
Paula Ravasco, Maria Ermelinda Camilo
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Pierre-Marie RoyPierre Asfar
Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a
L M NapolitanoS O Heard
© 2021 Meta ULC. All rights reserved