Abstract
Much of our present knowledge of glial cell function stems from studies of glioma cell lines, both rodent (C6, C6 polyploid, and TR33B) and human (1321N1, 138MG, D384, R-111, T67, Tp-276MG, Tp-301MG, Tp-483MG, Tp-387MG, U-118MG, U-251MG, U-373MG, U-787MG, U-1242MG, and UC-11MG). New methods such as patch clamp and Ca2+ imaging have lead to rapid progress the last few years in our knowledge about glial cells, where an unexpected presence and diversity of receptors and ion channels have emerged. Basic mechanisms related to membrane potential and K+ transport and the presence of voltage gated ion channels (Na+, inwardly rectifying K+, Ca(2+)-activated K+, Ca2+, and Cl- channels) have been identified. Receptor function and intracellular signaling for glutamate, acetylcholine, histamine, serotonin, cathecolamines, and a large number of neuropeptides (bradykinin, cholecystokinin, endothelin, opioids, and tachykinins) have been characterized. Such studies are facilitated in cell lines which offer a more homogenous material than primary cultures. Although the expression of ion channels and receptors vary considerably between different cell lines and comparative studies are rare, a few differences (compared to astrocytes in primary cult...Continue Reading
References
Jan 1, 1977·Journal of Neurochemistry·V J BalcarP Mandel
May 1, 1978·Journal of Neurochemistry·W J Nicklas, E T Browning
Jan 9, 1976·Brain Research·B HamprechtT Amano
Mar 5, 1976·Brain Research·G KukesJ De Vellis
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E GaleaD J Reis
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·W Walz
Jan 1, 1992·Acta Physiologica Scandinavica·N AltiokB B Fredholm
May 1, 1992·Journal of Neuro-oncology·J M OlsonW R Mancini
Jan 1, 1992·Glia·D ManorM Segal
Jan 1, 1992·Acta neurochirurgica·P CornuJ Philippon
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C MatuteR Miledi
Jun 1, 1992·Brain Research. Molecular Brain Research·T AmanoF Hishinuma
Feb 1, 1992·Journal of Neurochemistry·C L Johnson, C G Johnson
Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·B R Ransom, H Sontheimer
Sep 1, 1992·Journal of Neurochemistry·M L Simmons, S Murphy
Oct 2, 1992·Brain Research·M J Lucherini, E Gruenstein
Oct 2, 1992·Brain Research·S MedranoR V Dimlich
Dec 1, 1992·The American Journal of Physiology·A ParedesK Strange
Nov 1, 1992·Neuroreport·M N Wallace, K Fredens
Jan 1, 1992·Glia·M H Kim-LeeA J Yates
Jan 1, 1992·Glia·S Y WangG K Wang
Feb 1, 1991·Neuropathology and Applied Neurobiology·S LoveD Baines
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P W Tas, K Koschel
Jan 1, 1991·Glia·V DaveK D McCarthy
Apr 1, 1990·Neuron·B A BarresD P Corey
Feb 8, 1991·Brain Research·K H BackusH Kettenmann
Jan 1, 1991·Annals of the New York Academy of Sciences·S Supattapone, C C Ashley
Sep 1, 1991·Neuropeptides·M M GleasonN Aiyar
Dec 24, 1991·Brain Research·J L TomsigR V Dimlich
Sep 1, 1991·Annals of Neurology·P K StysB R Ransom
Nov 1, 1990·Neuroreport·M L DefendiniC Granier
Jan 1, 1990·Life Sciences·G E ThomasC J Coscia
Jun 25, 1990·Brain Research·J DeasM Erecińska
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F StaubO Kempski
Jan 1, 1990·Life Sciences·A Stiene-Martin, K F Hauser
Jan 8, 1990·Brain Research·G ReiserB Hamprecht
Sep 23, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S BevanJ M Ritchie
Sep 1, 1986·Neuroscience·F N Quandt, B A MacVicar
Jan 27, 1987·Brain Research·G ReiserB Hamprecht
Jun 1, 1987·The Journal of General Physiology·B S PallottaT K Harden
Oct 16, 1987·Biochimica Et Biophysica Acta·P W TasK Koschel
Nov 1, 1988·Journal of Neurochemistry·A J BalmforthS G Ball
Dec 5, 1988·Neuroscience Letters·P W TasK Koschel
Feb 1, 1988·Acta Physiologica Scandinavica·T Brismar, V P Collins
Jan 1, 1988·Glia·B A BarresD P Corey
Feb 20, 1989·Brain Research·T Brismar, V P Collins
Feb 20, 1989·Brain Research·T Brismar, V P Collins
Jan 1, 1989·Glia·J G McLarnon, S U Kim
May 29, 1989·Brain Research·C M LeeJ D Young
May 1, 1989·Brain Research·R LomnethE Gruenstein
Citations
Mar 12, 2009·Journal of Inherited Metabolic Disease·N KyprianouI Hargreaves
Nov 26, 2010·Purinergic Signalling·Dorota Supłat-WypychJolanta Barańska
Jan 7, 2004·Cell Calcium·Maria GalianoGiuseppe Cassano
Apr 20, 2004·Toxicology Letters·Alexandra RolletschekAnna M Wobus
May 7, 2003·Journal of Theoretical Biology·William I Newman, Jorge A Lazareff
Feb 7, 2002·Neurotoxicology·B Verones, M Oortgiesen
Oct 9, 1999·Neuroscience Research·M FukayaM Watanabe
May 29, 1998·Brain Research. Molecular Brain Research·T BíróP M Blumberg
Mar 17, 2000·Brain Research. Molecular Brain Research·A J Mothe, I R Brown
Jul 1, 1997·Neurochemistry International·P SabałaJ Barańska
Feb 17, 2000·Neurochemistry International·M WójcikJ Barańska
Jun 6, 1997·Neuroscience Letters·P WeydtH Kettenmann
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I PodkletnovaH Alho
Dec 17, 1998·Bone·K Schirrmacher, D Bingmann
Sep 30, 1998·The European Journal of Neuroscience·C LabrakakisH Kettenmann
Jul 9, 2009·Acta Physiologica·Y TakayasuS Ozawa
Jun 8, 2002·Annual Review of Neuroscience·David I Gottlieb
Jun 17, 2003·Biological & Pharmaceutical Bulletin·Yunjo SohSun Yeou Kim
Sep 3, 2010·PloS One·Iskandar F AbdullaevYu-Hung Kuo
Jan 22, 2013·PloS One·Ravi N VellankiAllen Volchuk
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean-Pierre MothetGérard Baux
Apr 3, 2001·Glia·R KraftS Patt
Nov 10, 1998·The Journal of Physiology·J Hartmann, A Verkhratsky
Feb 13, 2004·FEBS Letters·Giuliano MeyerMarkus Paulmichl
Jul 22, 2008·European Journal of Pharmacology·Patryk KrzemińskiJolanta Barańska
Mar 21, 2016·Biomaterials·A D GilmourR A Green
May 13, 2004·Glia·Xiao-Dong ZhangYasunobu Okada
Jan 14, 2004·British Journal of Pharmacology·Rafal CzajkowskiJolanta Baranska
Mar 16, 2007·The FEBS Journal·Patryk KrzemińskiJolanta Barańska
Sep 28, 2010·BioFactors·Nicola IoannouSimon J R Heales
Jul 26, 2011·Journal of Neurochemistry·Jin-Sun ParkHee-Sun Kim
Jan 1, 2005·Biosensors & Bioelectronics·Jaime CastilloJoshua Oni
Dec 8, 2004·Advances in Enzyme Regulation·Jolanta BarańskaPaweł Sabała
Sep 29, 2004·Cell Calcium·Maria GalianoGiuseppe Cassano
Jan 4, 2001·Biochemical Pharmacology·R dos Santos El-BacháA Minn
Dec 30, 2015·Nature Neuroscience·Stefanie Robel, Harald Sontheimer
May 10, 2003·Pflügers Archiv : European journal of physiology·Robert KraftStephan Patt
Sep 29, 1999·The Veterinary Record·N D Jeffery, W F Blakemore
Nov 14, 1997·Journal of Neurophysiology·M ShirahataJ S Sham
May 20, 1998·Journal of Neurophysiology·A Bordey, H Sontheimer
Sep 25, 2014·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V N Nikandrov, T V Balashevich
Jul 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·P R F RochaD M de Leeuw
Jun 15, 2007·Neurochemical Research·Mark J BelseyRoland Z Kozlowski
Feb 13, 2001·Journal of Neurophysiology·C B Ransom, H Sontheimer
Dec 29, 2016·Science Advances·Paulo R F RochaHenrique L Gomes
Sep 29, 1999·Journal of Neurochemistry·M SchwaningerM Spranger
Feb 11, 1998·Physiological Reviews·A VerkhratskyH Kettenmann
Jul 23, 2021·Advanced Science·Elise P W JenkinsGeorge G Malliaras
Sep 1, 2019·Bioelectricity·Paulo R F RochaDavid Tosh