Physostigmine induces in rats a phenomenon resembling long-term potentiation

European Journal of Pharmacology
T ItoT Kadokawa

Abstract

The study dealt with a phenomenon similar to long-term potentiation of hippocampal population spikes that was observed with a high dose of physostigmine given to rats. The population spikes in the dentate granule cells in anesthetized rats were enhanced to 135, 152 and 167% of the control level 60, 120 and 240 min after the administration of physostigmine (0.1 mg/kg i.v.), respectively. The time course of the enhancement was consistent with that of blocked paired pulse inhibition by physostigmine in anesthetized rats. Such a block of paired pulse inhibition was seen at the observation of the long-term potentiation phenomenon to tetanic stimulation (100 Hz, 2 s). Perfusion of physostigmine (10(-5) M) or bicuculline (10(-6) M) elicited second spikes following the population spikes in CA1 pyramidal cells. The second spikes elicited by physostigmine were decreased by scopolamine (10(-6) M) and muscimol (5 x 10(-7) M), while those caused by bicuculline were decreased by muscimol but not by scopolamine. It is suggested that physostigmine induces a long-term potentiation-like phenomenon through a transient, abrupt increase in excitability and the subsequent block of recurrent GABAergic inhibition in the hippocampus.

References

Sep 19, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J EcclesF J Rubia
Jul 1, 1985·Canadian Journal of Physiology and Pharmacology·N Ropert
Aug 1, 1988·Canadian Journal of Physiology and Pharmacology·T ItoT Kadokawa
Jan 1, 1973·Neuropharmacology·A BartoliniE F Domino
Oct 28, 1982·Brain Research·J V Halliwell, P R Adams
Mar 1, 1984·Brain Research·T J Teyler, P Discenna
Jan 1, 1983·Psychopharmacology·G N BritoM E Stanton

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Citations

Nov 3, 1994·European Journal of Pharmacology·Y Levkovitz, M Segal
Dec 1, 1992·Brain Research Bulletin·C FrankA Scotti de Carolis
Oct 3, 2003·Neurobiology of Learning and Memory·Ann E PowerJames L McGaugh
Sep 1, 1992·British Journal of Pharmacology·J A MillerJ M Kane
May 27, 2008·Neuroscience Letters·Eunjin ParkChang-Joong Lee
Jun 25, 1990·Brain Research·D A EngstromG M Rose
Jan 14, 1999·Reviews in the Neurosciences·V G Skrebitsky, A N Chepkova
Dec 7, 2010·Behavioural Brain Research·Benjamin D DreverBettina Platt

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