Phyto-synthesis of silver nanoparticles using Alternanthera tenella leaf extract: an effective inhibitor for the migration of human breast adenocarcinoma (MCF-7) cells

Bioprocess and Biosystems Engineering
Palanivel SathishkumarThayumanavan Palvannan

Abstract

In this study, phyto-synthesis of silver nanoparticles (AgNPs) was achieved using an aqueous leaf extract of Alternanthera tenella. The phytochemical screening results revealed that flavonoids are responsible for the AgNPs formation. The AgNPs were characterised using UV-visible spectrophotometer, field emission scanning microscopy/energy dispersive X-ray, transmission electron microscopy, fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction. The average size of the nanoparticles was found to be ≈48 nm. The EDX results show that strong signals were observed for the silver atoms. The strong band appearing at 1601-1595 cm(-1) correspond to C-C stretching vibration from dienes in FT-IR spectrum indicating the formation of AgNPs. Human breast adenocarcinoma (MCF-7) cells treated with various concentrations of AgNPs showed a dose-dependent increase in cell inhibition. The IC50 value of the AgNPs was calculated to be 42.5 μg mL(-1). The AgNPs showed a significant reduction in the migration of MCF-7 cells.

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Citations

Aug 20, 2016·Journal of Photochemistry and Photobiology. B, Biology·Palanivel SathishkumarThayumanavan Palvannan
Sep 9, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Preethi JohnsonThayumanavan Palvannan
Jun 13, 2018·International Journal of Molecular Sciences·Nurul Akma HananVuanghao Lim
Apr 22, 2021·Microscopy Research and Technique·Saima AliRaees Khan
Apr 30, 2020·Saudi Journal of Biological Sciences·Asma S AlgebalyMudawi M Elobeid
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jolanta FliegerPrzemysław Kołodziej

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