Phytoalexins of the Pyrinae: Biphenyls and dibenzofurans.

Beilstein Journal of Organic Chemistry
Cornelia Chizzali, Ludger Beerhues

Abstract

Biphenyls and dibenzofurans are the phytoalexins of the Pyrinae, a subtribe of the plant family Rosaceae. The Pyrinae correspond to the long-recognized Maloideae. Economically valuable species of the Pyrinae are apples and pears. Biphenyls and dibenzofurans are formed de novo in response to infection by bacterial and fungal pathogens. The inducible defense compounds were also produced in cell suspension cultures after treatment with biotic and abiotic elicitors. The antimicrobial activity of the phytoalexins was demonstrated. To date, 10 biphenyls and 17 dibenzofurans were isolated from 14 of the 30 Pyrinae genera. The most widely distributed compounds are the biphenyl aucuparin and the dibenzofuran γ-cotonefuran. The biosynthesis of the two classes of defense compounds is not well understood, despite the importance of the fruit crops. More recent studies have revealed simultaneous accumulation of biphenyls and dibenzofurans, suggesting sequential, rather than the previously proposed parallel, biosynthetic pathways. Elicitor-treated cell cultures of Sorbus aucuparia served as a model system for studying phytoalexin metabolism. The key enzyme that forms the carbon skeleton is biphenyl synthase. The starter substrate for this typ...Continue Reading

References

Jan 1, 1995·Plant Physiology·J. Chappell
Nov 17, 2006·Planta·B LiuL Beerhues
May 25, 2007·Advances in Biochemical Engineering/biotechnology·Cesare Gessler, Andrea Patocchi
Sep 17, 2009·Plant Molecular Biology·Benye LiuLudger Beerhues
Oct 22, 2010·Journal of Agricultural and Food Chemistry·Cornelia HüttnerLudger Beerhues

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Citations

Jul 22, 2014·Angewandte Chemie·Hülya AldemirTobias A M Gulder
Jan 15, 2015·European Journal of Medicinal Chemistry·Brian E Love
May 29, 2015·The Plant Journal : for Cell and Molecular Biology·Mohammed N A KhalilLudger Beerhues
May 4, 2016·Development Genes and Evolution·Vijayanathan MallikaEppurathu Vasudevan Soniya
Feb 13, 2016·Natural Product Reports·Marion MillotSophie Tomasi
Sep 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liangyun ZhouLanping Guo
Oct 24, 2018·Frontiers in Plant Science·Rozaimi RazaliSónia Negrão
Dec 4, 2019·Angewandte Chemie·Vincent C FäsekeChristof Sparr
Sep 25, 2020·PloS One·Annmarie-Deetja RohrTraud Winkelmann
Feb 16, 2021·FEMS Microbiology Ecology·Alicia Balbín-SuárezKornelia Smalla
Dec 14, 2017·The Journal of Organic Chemistry·Ji Young ChoEun Jin Cho

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