Phytochemical analysis and antinociceptive properties of the seeds of Garcinia achachairu

Archives of Pharmacal Research
Marlova Manhabosco Dal MolinRivaldo Niero

Abstract

In a search for new and effective analgesic substances from the Brazilian biodiversity, the present study evaluates the chemical composition and antinociceptive potential of the methanol extract and a pure compound obtained from the seeds of Garcinia achachairu Rusby (Clusiaceae). The methanolic seed extract was directly subjected to purification by column chromatography and the purification was monitored by thin-layer chromatography. The main isolated compound was identified as Guttiferone A by comparison of conventional spectroscopic data (IR, NMR-(1)H and (13)C) to the literature data which was isolated for the first time from this plant. When evaluated in the acetic acid-induced nociception model in mice, the methanolic seed extract had an ID(50) (Inhibitory dose) of 13.1 (11.23-14.91) mg/kg and a maximal inhibition of 72 ± 4%. In the same model, Guttiferone A had an ID(50) of 4.54 (3.29-6.24) mg/kg and a maximal inhibition of 73 ± 5%. The methanolic seed extract and Guttiferone A were also active in pain models induced by formalin, capsaicin, glutamate and carrageenan. These data suggest that the antinociceptive effect of Guttiferone A partly depends on its interference with the synthesis or activity of the cytokine TNF-α,...Continue Reading

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Citations

Dec 26, 2015·Pharmaceutical Biology·Luisa Nathália Bolda MarianoRivaldo Niero
Aug 11, 2015·Journal of Ethnopharmacology·Francis Desire Tatsinkou BombaTelesphore Benoit Nguelefack
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Valdir Cechinel FilhoAngela Malheiros
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Mst Mahfuza KhatoonMst Shahnaj Parvin
May 23, 2012·Journal of Ethnopharmacology·Eduardo de Souza MarquesEdson Luis Maistro
Sep 26, 2019·Inflammopharmacology·Roberta NunesNara Lins Meira Quintão
May 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Luísa Nathália Bolda MarianoPriscila de Souza

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