Phytochemical analysis and evaluation of the antioxidant and antiproliferative effects of Tucumã oil nanocapsules in breast adenocarcinoma cells (MCF-7).

Natural Product Research
Kátia NascimentoJosé Edson Paz da Silva

Abstract

In this work was to develop an inedited nanocapsule with tucumã oil (Astrocaryum vulgare). The oil presents of phytosterols (squalene and β-sitosterol), all-trans-beta-carotene, acids oleic and palmitic. Antioxidant activity showed a good performance in DPPH and ABTS assays. The nanocapsules were prepared and demonstrated in their characterization particle size (206 ± 0.69 nm). The cytogenotoxicity evaluation was performed using the MTT, dichlorofluorescein, nitric oxide and dsDNA PicoGreen® assays. Antitumor efficacy assays in MCF-7 cells demonstrated that free oil and tucumã nanocapsules had IC50 of 130 and 50 μg/mL, respectively. Thus, previous studies of toxicity are relevant, as they generate future subsidies, aiming at the potential application of nanostructures and in addition, the promising effect of NCs of tucumã oil on the antiproliferative effect in breast adenocarcinoma cells was evidenced.

References

Jan 29, 2003·Cancer Metastasis Reviews·Omer Kucuk
Jun 30, 2004·International Journal of Food Sciences and Nutrition·L S MaguireN M O'Brien
Jun 14, 2005·Biochimica Et Biophysica Acta·Ruan Elliott
Oct 8, 2005·Oncology·Hoyoku NishinoKenji Jinno
Mar 14, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A B AwadP G Bradford
Jul 21, 2009·Dental Materials : Official Publication of the Academy of Dental Materials·Ninghua KongJuanling Fu
Oct 15, 2009·International Journal of Pharmaceutics·C E Mora-HuertasA Elaissari
Feb 15, 2011·Advanced Drug Delivery Reviews·Libo WuWiwik Watanabe
Feb 24, 2012·International Journal of Nanomedicine·Shann S YuTodd D Giorgio
Sep 3, 2013·Food Chemistry·Kleidson Brito de Sousa LobatoAlessandro de Oliveira Rios
Dec 4, 2014·Food Chemistry·Michele Rorato SagrilloIvana Beatrice Mânica da Cruz
Mar 26, 2015·Bioorganic & Medicinal Chemistry Letters·Brett LomenickChuo Chen
Mar 23, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Gaël Le RouxFrédéric Lagarce

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.