Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands)

Natural Product Research
Alessandro VendittiFelice Senatore

Abstract

A complete chemical investigation of Achillea ligustica All. growing at Lipari (Aeolian Island, Sicily) has been carried out. Seventeen metabolites have been isolated and characterised from dichloromethane and methanol extracts of flowers and aerial parts, and GC/MS analyses of petroleum ether extracts was carried out, revealing a composition in sesquiterpenoids similar to those reported for populations from Greece, Sicily and Algeria, showing the presence of (3RS,6RS)-2,6-dimethyl-1,7-octadiene-3,6-diol (1), 2,6-dimethyl-octa-3(E),7-diene-2,6-diol (2), iso-seco-tanapartholide (3) from DCM fraction. In addition from the methanolic extract of the aerial parts, peculiar flavonoid glucuronides have been isolated: i.e. apigenin-7-O-glucuronide (12) and quercetin 3-O-glucuronide (14). These metabolites have been reported in this species for the first time. The isolated flavonoids were previously recognised in several species of this complex genus and for this reason seems to be highly retained secondary metabolites of importance from the chemotaxonomic point of view.

References

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Citations

Nov 24, 2016·Natural Product Research·Diego A SampietroCesar A Catalán
Mar 17, 2019·International Journal of Molecular Sciences·Bahare SalehiNatália Martins
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
Apr 10, 2021·Oxidative Medicine and Cellular Longevity·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Coralia CotoraciAnca Hermenean
Nov 26, 2021·Journal of Biomolecular Structure & Dynamics·Mustafa Abdullah YılmazErcan Bursal

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Methods Mentioned

BETA
NMR
H

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