Phytochemical and in vitro and in vivo biological investigation on the antihypertensive activity of mango leaves (Mangifera indica L.)

Therapeutic Advances in Cardiovascular Disease
Silas Nascimento RonchiTadeu Uggere de Andrade

Abstract

The aim of this study was to investigate the antihypertensive effect of leaves Mangifera indica L. using in vitro and in vivo assays. The ethanol extract of leaves of M. indica was fractionated to dichloromethanic, n-butyl alcohol and aqueous fractions. The chemical composition of ethanolic extract and dichloromethanic fraction were evaluated by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Antioxidant activity was evaluated in the DPPH scavenging activity assay. Angiotensin-converting enzyme (ACE) inhibitory activity was investigated using in vitro and in vivo assays. The chronic antihypertensive assay was performed in spontaneously hypertensive rats (SHRs) and Wistar rats treated with enalapril (10 mg/kg), dichloromethanic fraction (100 mg/kg; twice a day) or vehicle control for 30 days. The baroreflex sensitivity was evaluated through the use of sodium nitroprusside and phenylephrine. Cardiac hypertrophy was evaluated by morphometric analysis. The dichloromethanic fraction exhibited the highest flavonoid, total phenolic content and high antioxidant activity. Dichloromethanic fraction elicited ACE inhibitory activity in vitro (99 ± 8%) similar to captopril. LC-MS/MS analysis revealed the presence of ...Continue Reading

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Citations

May 11, 2016·Nutrition·Dorina Isabel Gomes NatalHércia Stampini Duarte Martino
May 6, 2016·Fundamental & Clinical Pharmacology·Denise G TerraTadeu U de Andrade
Jul 2, 2019·Chemical & Pharmaceutical Bulletin·Yi ZhangTao Wang
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Feb 16, 2021·Molecular and Cellular Biochemistry·Bhoomika PatelMahaveer Dhobi

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