Phytochemical, Antioxidant and Anti-Cancer Properties of Euphorbia tirucalli Methanolic and Aqueous Extracts

Antioxidants
Benjamin MunroChristopher J Scarlett

Abstract

Euphorbia tirucalli is a succulent shrub or small tree that is native to the African continent, however, it is widely cultivated across the globe due to its use in traditional medicines to treat ailments, ranging from scorpion stings to HIV. Recent studies have identified compounds present in the latex of the plant, including a range of bi- and triterpenoids that exhibit bioactivity, including anticancer activity. This study aimed to optimize water extraction conditions for high-yield total phenolic content recovery, to prepare methanol and aqueous extracts from the aerial sections of the plant, and to test the phytochemical, antioxidant, and anti-cancer properties of these extracts. Water extraction of total phenolic compounds (TPC) was optimized across a range of parameters including temperature, extraction time, and plant mass-to-solvent ratio. The water extract of the E. tirucalli powder was found to contain TPC of 34.01 mg GAE (gallic acid equivalents)/g, which was approximately half that of the methanol extract (77.33 mg GAE/g). The results of antioxidant assays showed a uniform trend, with the methanol extract's antioxidant reducing activity exceeding that of water extracts, typically by a factor of 2:1. Regression analy...Continue Reading

References

Apr 24, 2008·Journal of Natural Medicines·Kubsad Parameshwarappa ChannabasavarajSuresh Bhojraj
Jun 6, 2009·Antioxidants & Redox Signaling·Georg T Wondrak
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin Dai, Russell J Mumper
May 29, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Wei LinYaw-Bin Huang
Jan 1, 2014·Antioxidants·Keline Medeiros de AraújoReginaldo Almeida da Trindade

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Citations

Aug 17, 2018·Experimental and Therapeutic Medicine·Viviane Aline Oliveira SilvaRui M Reis
Apr 15, 2016·Phytotherapy Research : PTR·Antonella SmeriglioClara Circosta
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kishor MazumderKoichi Fukase

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Software Mentioned

SPSS
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