Phytochemical characterization and antioxidant, antibacterial and antimutagenic activities of aqueous extract from leaves of Alchornea glandulosa

Journal of Toxicology and Environmental Health. Part a
Douglas Costa GontijoJoão Paulo Viana Leite

Abstract

Plant extracts exist as a complex matrix which serves as a source of numerous bioactive metabolites. The ultra performance liquid chromatography with diode-array detection-coupled electrospray ionization-mass spectrometry/mass spectrometry technique was used to characterize the aqueous extract from leaves of Alchornea glandulosa (EAG), a species popularly used to treat gastrointestinal problems as an antiulcer agent. Quantification of phenolic derivatives was determined using Folin-Ciocalteu and aluminum trichloride (AlCl3) methods. In addition, antioxidant (2,2-diphenyl-1-picrylhydrazyl [DPPH•] radical scavenging, β-carotene-linoleic acid, and lipid peroxidation), antibacterial (agar well diffusion method and minimum inhibitory concentration), antimutagenic (Ames test), and antigenotoxic (plasmid cleavage) assays were also performed on this plant extract. The ellagitannin tris-galloyl-hexahydroxydiphenic acid-glucose was identified as the predominant compound along with tannins as majority metabolites. EAG showed high antioxidant activity accompanied by moderate antibacterial activity against Staphylococcus aureus. The highest antimutagenic activity was observed for TA97 strain without metabolic activation (S9) and with metabo...Continue Reading

References

May 1, 1983·Mutation Research·D M Maron, B N Ames
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D E LevinB N Ames
Jul 25, 2000·Toxicology Letters·J C de MattosA Caldeira-de-Araújo
Dec 13, 2000·Mutation Research·K Mortelmans, E Zeiger
Apr 20, 2001·Journal of Applied Microbiology·R Puupponen-PimiäK M Oksman-Caldentey
May 26, 2004·Fitoterapia·A Urrea-BullaB Moreno-Murillo
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Flávia Cristine Mascia LopesIracilda Zeppone Carlos
Dec 17, 2005·Antioxidants & Redox Signaling·Amit K GargBharat B Aggarwal
Jan 16, 2009·BMC Complementary and Alternative Medicine·Michael F JohnstonKa-Kit Hui
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Feb 18, 2010·International Journal of Molecular Sciences·Takashi YoshidaMorio Yoshimura
May 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Virginie GranciClaude Pichard
Jun 24, 2010·Clinical Neuropathology·H ForeidJ Pimentel
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kanti Bhooshan Pandey, Syed Ibrahim Rizvi
Mar 2, 2011·Pharmacology & Therapeutics·Nam Joo KangKi Won Lee
Oct 4, 2011·Journal of Pharmacy & Bioallied Sciences·Sabiha SumbulAkhtar Mohd
Jan 11, 2012·Journal of Agricultural and Food Chemistry·Marja KähkönenMarina Heinonen
Feb 28, 2014·Journal of Agricultural and Food Chemistry·Richard Pereira DutraRosane Nassar Meireles Guerra
Mar 7, 2014·Journal of Toxicology and Environmental Health. Part a·María del Carmen García-RodríguezMario Agustín Altamirano-Lozano
May 13, 2015·European Journal of Nutrition·Claudia Sánchez-GonzálezVéronique Noé
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Eleonora TurriniCarmela Fimognari
Dec 2, 2015·Journal of Chemical Information and Modeling·Yenny Villuendas-ReyAnnia Galano
Jan 17, 2016·Annual Review of Food Science and Technology·Annia GalanoNino Russo
Sep 3, 2016·Journal of Toxicology and Environmental Health. Part a·Cristiano TrindadeJoão Antonio Pêgas Henriques
Mar 18, 2017·Journal of Toxicology and Environmental Health. Part a·Erico R CarmonaClaudio Inostroza-Blancheteau
Aug 22, 2017·Journal of Pharmaceutical and Biomedical Analysis·Markus Ganzera, Sonja Sturm
Sep 9, 2017·Journal of Cellular Physiology·Tiziana SquillaroMariarosa A B Melone
Sep 29, 2017·Journal of Toxicology and Environmental Health. Part a·Nathália Oliveira AcésioDenise Crispim Tavares
Oct 12, 2017·Journal of Toxicology and Environmental Health. Part a·Antonio Ivanildo PinhoJeferson Luis Franco
Dec 30, 2017·Journal of Toxicology and Environmental Health. Part a·Jacqueline Morais AlvesDenise Crispim Tavares
Mar 24, 2018·Environmental and Molecular Mutagenesis·Zahira Fernández-BedmarÁngeles Alonso Moraga
Apr 10, 2018·Journal of Toxicology and Environmental Health. Part a·Gwang-Ho JoYong Heo

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Citations

Mar 9, 2019·Journal of Toxicology and Environmental Health. Part a·Tamiris Alves RochaMaria Tereza Dos Santos Correia
May 9, 2019·Journal of Toxicology and Environmental Health. Part a·Nayane Moreira MachadoDenise Crispim Tavares
Jul 19, 2019·Journal of Toxicology and Environmental Health. Part a·Sandra Mara DuavyNilda Vargas Barbosa
Jun 23, 2020·Journal of Toxicology and Environmental Health. Part a·Jurandy do Nascimento SilvaPaulo Michel Pinheiro Ferreira
Jun 28, 2020·Journal of Toxicology and Environmental Health. Part a·Higor Lopes NunesIlce Mara de Syllos Cólus
Oct 27, 2020·Journal of Toxicology and Environmental Health. Part a·Bruno Coêlho CavalcantiManoel Odorico Moraes

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

ImageJ
SigmaPlot

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