Phytochemical composition analysis and evaluation of in vitro medicinal properties and cytotoxicity of five wild weeds: A comparative study.

F1000Research
Pranabesh GhoshSirshendu Chatterjee

Abstract

Background: Medicinal plants are a source of phytochemicals and they are used for the treatment of several oxidative stress-related or other diseases for their effectiveness, low toxicity and easy availability. Five traditionally used and less characterized herbaceous weeds of West Bengal, India, namely, Heliotropium indicum, Tridax procumbens, Cleome rutidosperma, Commelina benghalensis and Euphorbia hirta, were investigated for the current research study. Methods: Aqueous and 70% ethanolic extracts of the leaves were analyzed for estimation of essential phytochemicals and to evaluate their in vitro antioxidant status, medicinal properties and cytotoxic effects. To the best of our knowledge, several assays and comparative evaluations using these herbs are reported for the first time. For quantitative study, UV-vis spectrophotometry and high-performance liquid chromatography with diode array detector HPLC-DAD techniques were used. Antibacterial properties were investigated using the Kirby-Bauer disc diffusion method. For in vitro anti-lithiatic study, a titration method was used. The cell viability assay was done using peripheral blood mononuclear cells. Results: The aqueous extract exhibits higher content of polyphenols, flavo...Continue Reading

References

Feb 1, 1977·Analytical Biochemistry·H EsterbauerM Hayn
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Aug 24, 2000·Journal of Agricultural and Food Chemistry·L R Fukumoto, G Mazza
Apr 25, 2008·Current Protocols in Immunology·W Strober
Feb 26, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lars Mueller, Volker Boehm
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Abu Arra BasmaSreenivasan Sasidharan
Feb 4, 2012·Indian Journal of Pharmaceutical Sciences·Nilima S Rajurkar, S M Hande
Apr 14, 2016·Oxidative Medicine and Cellular Longevity·Chunye Chen
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Truong Ngoc MinhHoang-Dung Tran
Apr 3, 2019·F1000Research·Harlinda KuspradiniIrawan Wijaya Kusuma

❮ Previous
Next ❯

Citations

Nov 24, 2020·F1000Research·Sandra Catalina Garzón-CastañoJuan Carlos Sepúlveda-Arias

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
blood drawn

Software Mentioned

MS Excel
Origin Pro
Open Lab CDS
BR
NIS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.