Phytochemical composition of essential oil from seeds of Zingiber roseum Rosc. and its antispasmodic activity in rat duodenum

Journal of Ethnopharmacology
Om PrakashC S Mathela

Abstract

A combination of GC and GC-MS revealed the presence of 60 compounds out of which 47 compounds (96.2% of the oil) were identified in the essential oil of seeds of Zingiber roseum Rosc., the major compounds being alpha-pinene, beta-pinene, limonene, p-cymene, alpha-terpineol and verticiole. The unique feature is the dominant presence of mono- and sesquiterpene hydrocarbons which make about 82% of the oil. The oil showed myorelaxant activity on isolated rat duodenal smooth muscle. The Zingiber roseum seed essential oil (ZRSEO) relaxed both cabachol- and KCl-induced contractile responses with IC(50) of non-significant difference. The results confirm a common mechanism in both the types of action of ZRSEO and suggests a probable inhibitory effect of ZRSEO on influx of Ca(2+) through cell membrane of rat duodenal smooth muscle.

References

Jul 1, 1987·Journal of Natural Products·A T BottiniC S Mathela
Oct 1, 1984·Journal of Comparative Pathology·P K ChakravartyJ R Chowdhury
Oct 31, 2000·Phytotherapy Research : PTR·M A BezerraM C Fonteles

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Citations

Dec 19, 2012·Journal of Pharmacy & Bioallied Sciences·Sabiha SumbulIbne Saud
Apr 3, 2012·Drug Discoveries & Therapeutics·K SaeioS Okonogi
Nov 26, 2008·Journal of Ethnopharmacology·Peerarat ThainaSanan Subhadhirasakul
Mar 1, 2009·Journal of Acupuncture and Meridian Studies·Seyed Hassan Hejazian-YMasood Anvar Qureshi
Mar 31, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Amanda Sánchez-RecillasRolffy Ortiz Andrade
Nov 8, 2018·BioMed Research International·Edith Fabiola Martínez-PérezHoracio Bach
May 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammed AmanatA F M Shahid Ud Daula

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