Phytochemical investigation of Gynura bicolor leaves and cytotoxicity evaluation of the chemical constituents against HCT 116 cells

Natural Product Research
Wuen Yew TeohKae Shin Sim

Abstract

Gynura bicolor (Compositae) is a popular vegetable in Asia and believed to confer a wide range of benefits including anti-cancer. Our previous findings showed that the ethyl acetate extract of G. bicolor possessed cytotoxicity and induced apoptotic and necrotic cell death in human colon carcinoma cells (HCT 116). A combination of column chromatography had been used to purify chemical constituents from the ethyl acetate and water extract of G. bicolor leaves. Eight chemical constituents 5-p-trans-coumaroylquinic acid (I), 4-hydroxybenzoic acid (II), rutin (III), kampferol-3-O-rutinoside (IV), 3,5-dicaffeoylquinic acid (V), kampferol-3-O-glucoside (VI), guanosine (VII) and chlorogenic acid (VIII) were isolated from G. bicolor grown in Malaysia. To our best knowledge, all chemical constituents were isolated for the first time from G. bicolor leaves except rutin (III). 3,5-dicaffeoylquinic acid (V), guanosine (VII) and chlorogenic acid (VIII) demonstrated selective cytotoxicity (selective index>3) against HCT 116 cancer cells compared to CCD-18Co human normal colon cells.

References

Oct 6, 2000·Phytochemistry·Y LuA L Molan
Sep 19, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C BézivinJ Boustie
Nov 4, 2009·The American Journal of Chinese Medicine·Wei-Lin LiShi Sun
Jan 1, 2013·Journal of Traditional and Complementary Medicine·Chih-Chung WuShu-Ling Hsieh

❮ Previous
Next ❯

Citations

Oct 21, 2017·Natural Product Research·Qinge MaZhongling Cao
May 7, 2019·Journal of Food Science·Pei-Ying PaiMei-Chin Yin
May 17, 2019·Chemistry & Biodiversity·Cinthia Indy TamayoseMarcelo J Pena Ferreira
Jul 11, 2020·Natural Product Research·Yan WangMuhammad Iqbal Choudhary
Mar 23, 2017·Nucleosides, Nucleotides & Nucleic Acids·Wuen Yew TeohKae Shin Sim
Sep 22, 2017·Advances in Bioinformatics·Lina RozanoIndu Bala Jaganath
May 28, 2019·BioMedicine·Ya-Chen YangZhi-Hong Wang
Jan 20, 2021·Journal of Ethnopharmacology·Md Sazzadul BariMohammad Abdur Rashid
Jun 26, 2021·The Plant Journal : for Cell and Molecular Biology·Armando Alcázar MagañaClaudia S Maier

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Evidence-based Complementary and Alternative Medicine : ECAM
Wuen Yew TeohSee Ziau Hoe
BMC Complementary and Alternative Medicine
Nidyaletchmy Subba ReddyKae Shin Sim
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Xin-An HuangYu-Hu Zhang
Yao xue xue bao = Acta pharmaceutica Sinica
Kai-Zhou FuYi-Min Zhao
© 2022 Meta ULC. All rights reserved