Phytochemical profiles and biological activity evaluation of Zanthoxylum bungeanum Maxim seed against asthma in murine models

Journal of Ethnopharmacology
Weizhuo TangYuqing Zhao

Abstract

Zanthoxylum bungeanum Maxim seed (ZBMS) has been used in Traditional Chinese Medicine (TCM) as an ingredient of polyherbal formulations for the treatment of inflammation and asthma. The aim of this study was to analyze the major composition and to evaluate the anti-asthma activity of ZBMS. Some murine models including acetylcholine/histamine-induced asthma, ovalbumin-induced airway inflammation, ear edema and toe swelling measurement, citric acid-induced cough, and anti-stress abilities were investigated to fully study the anti-asthma activity of ZBMS.GC chromatography was also performed to analyze the major fatty acid composition of ZBMS. The results demonstrated that the major fatty acid composition of ZBMS includes oleic acid (20.15%), linoleic acid (26.54%), and α-linolenic acid (30.57%), which was the leading component of ZBMS, and that the total fatty acid content of ZBMS was 77.27%. The murine models demonstrated that ZBMS displays a protective effect on guinea pig sensitization, a dose-dependent inhibition of the increases in RL and decreases in Cdyn, which resulted in the relief of auricle edema and toe swelling in mice and anti-stress activity. Our results validate the traditional use of ZBMS for the treatment of asth...Continue Reading

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Citations

Apr 5, 2016·Journal of Ethnopharmacology·Keyou LiTiancun Xiao
Jul 24, 2014·Acta histochemica·Aline Donato-TrancosoBruna Romana-Souza
May 29, 2016·Journal of Separation Science·Rong RongYun-Li Zhao
May 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xi ChenChunjie Wu
Aug 10, 2018·Chemistry & Biodiversity·Christine PerichetNicole Giraud
Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Aleksandra ShedoevaChen Fan
Apr 18, 2019·The Journal of Pharmacy and Pharmacology·Mohammad Hossein BoskabadyRamin Rezaee
Sep 6, 2018·Current Medicinal Chemistry·Danka BukvickiAmit Kumar Tyagi

Related Concepts

Asthma
Dose-Response Relationship, Drug
Anasarca
Cavia porcellus
Inflammation
Traditional Chinese Medicine
Ovalbumin
Plant Extracts
Rats, Holtzman
Anti-Asthmatic Agents

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