Phytochemical profiling and ameliorative effects of Achillea cretica L. on rat model of endometriosis

Journal of Ethnopharmacology
Fatemeh BinaRoja Rahimi

Abstract

Achillea cretica (AC) is a medicinal plant emphasized for treatment of gynecological disorders and pathological symptoms similar to endometriosis in traditional Persian medicine. Since information about its chemical constituents is limited, the aim of this study is to investigate phenolic composition of AC extract as well as its effect on experimental model of endometriosis. RP-HPLC-PDA-ESI-MS/MS analysis was used for the determination of polyphenolic compounds. Endometriosis was induced in rats by suturing of uterus segments to abdominal wall of same rat, after eight weeks when the model was induced, it was followed by 28 days of treatment with 100, 200, and 400 mg/kg/day of hydroethanolic extract of the plant. Blood samples and implanted tissues were collected in the final day, and area of foci, tumor necrosis factor-α, vascular endothelial growth factor, interleukin-6, and serum total thiol molecules were measured and compared with positive group (0.2 mg/kg/day letrozole) and control group (solvent of extract: normal saline). Implanted tissue sections of the sacrificed rats were also assessed histopathologically. Nine polyphenolic compounds were identified in AC extract including 7 flavonoids and 2 phenolic acids. Plant extr...Continue Reading

Citations

Apr 10, 2021·Oxidative Medicine and Cellular Longevity·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
Aug 28, 2021·Nutrients·Ludovica BartiromoMassimo Candiani

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