Phytochemical Screening of Quaking Aspen (Populus tremuloides ) Extracts by UPLC-QTOF-MS and Evaluation of their Antimicrobial Activity

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Annabelle St-PierreIsabel Desgagné-Penix

Abstract

The continual emergence of pathogen resistance is a recurring challenge and pushes for the development of antimicrobial compounds. Here, we investigated compounds from quaking aspen trees (Populus tremuloides) as potential antimicrobial agents. Several extractions using different solvents were realized, and corresponding antimicrobial activity was tested against eight microorganisms. Results revealed that polar extraction solvents including water, ethanol and methanol gave the best extraction yields (>15.07%). Minimal inhibition concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC) demonstrated that water extracts had the best antimicrobial activity by a weak to moderate inhibition of growth of all eight tested microorganisms in addition to having a bactericidal effect on three of them. The quaking aspen methanol extract also displayed antimicrobial activity but to a lower level than the water extract. Ultra-performance liquid chromatography quadrupole time-of flight mass spectrometry (UPLC-QTOF-MS) analysis led to the identification of 92 compounds, mainly polyphenols in both extracts, with 22 molecules previously known for their antimicrobial properties. According to the relative abundance, 4-hydroxy...Continue Reading

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Citations

Jul 26, 2019·International Journal of Environmental Research and Public Health·Jingyi ZhuShunshan Duan
Apr 23, 2020·Frontiers in Pharmacology·Emmanuelle LautiéJean A Boutin

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