Phytochemical standardization and biological activities of certain desert plants growing in Saudi Arabia

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Muneera S Al-SaleemSaleh I Alqasoumi

Abstract

The phytochemical screening, antimicrobial and antitumor activities of Calendula tripterocarpa, Centarea sinaica, Centaurea pseudosinaica, Koelpinia linearis, Plectranthus arabicus, Plectranthus asirensis and Tripleurospermum auriculatum determined. The best antibacterial activity; 41.8 ± 0.23 mm, 39.7 ± 0.25 mm, 35.8 ± 0.58 mm, 34.7 ± 0.51 mm and 32.7 ± 0.25 mm was obtained by Plectranthus arabicus against Klebsiella pneumonia, Tripleurospermum auriculatum against Bacillus subtilis, Centaurea pseudosinaica against Bacillus subtilis, Centaurea pseudosinaica against Stroptococcus pyogenes and Plectranthus arabicus against Staphylococcus epidermidis, respectively. While the highest antifungal activity; 35.9 ± 1.15 mm, 34.6 ± 0.34, 30.6 ± 0.26 mm and 29.9 ± 0.63 mm was obtained by Tripleurospermum auriculatum against Geotricum candidum, Candida albicans, C. tropicalis and Aspergillus fumigatus, respectively. The antitumor activity (IC50) obtained by Centarea sinaica; 3.1 ± 6.9 µg/ml, 14.3 ± 3.1 µg/ml and 22.7 ± 4.1 µg/ml was better than activity of vinblastine sulphate; 5.9 ± 0.4 µg/ml, 59.7 ± 2.1 µg/ml and 30.3 ± 1.4 µg/ml against breast carcinoma (MCF-7), cervical carcinoma (Hela) and colorectal carcinoma (CACO), respectively. P...Continue Reading

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