Phytochemicals as Dynamic Surface Ligands To Control Nanoparticle-Protein Interactions

ACS Omega
Amanda N AbrahamRavi Shukla

Abstract

The rapid formation of the protein corona on to the nanoparticle (NP) surface is the key that confers biological identity to NPs and subsequently dictates their fate both in vitro and in vivo. Despite significant efforts, the inability to control the spontaneous interaction of serum proteins with the administered NPs remains a major constraint in clinical translation of nanomedicines. The ligands present on the NP surface offer promise in controlling their biological interactions; however, their influence on the NP-protein interaction is not well-understood. The current study investigates the potential of phytochemical-capped silver nanoparticles (AgNPs) toward allowing a control over NP interactions with the human serum albumin (HSA), the most abundant protein in the biological fluids. Specifically, we demonstrate the ability of curcumin (Cur) and epigallocatechin-3-gallate (EGCG) to independently act as reducing agents to produce phytochemical-capped AgNPs that show biologically desirable interactions with HSA. The key finding of our study is that the phytochemical-capped AgNPs initially interact with HSA more strongly compared to the citrate-stabilized AgNPs; however, the resultant NP-HSA complexes are less stable in the cas...Continue Reading

References

Nov 1, 2000·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·E L Gelamo, M Tabak
Sep 21, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Scott H BrewerStefan Franzen
Jan 8, 2008·Journal of Photochemistry and Photobiology. B, Biology·Ajay Kumar Shaw, Samir Kumar Pal
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Sep 8, 2009·Nature Nanotechnology·Carlheinz RöckerG Ulrich Nienhaus
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ravi ShuklaKattesh V Katti
Nov 13, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Stefano P BoulosCatherine J Murphy
Apr 10, 2014·Journal of Agricultural and Food Chemistry·Min Li, Ann E Hagerman
Jul 18, 2014·Journal of Molecular Modeling·Durg Vijay SinghKrishna Misra
Aug 12, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Wanju ZhangYi Liu
Mar 20, 2015·Cell Biology International·Sara SalatinAhmad Yari Khosroushahi
Jun 13, 2015·Journal of Photochemistry and Photobiology. B, Biology·Subramanian Ambika, Mahalingam Sundrarajan
Jun 25, 2015·The Journal of Physical Chemistry. B·Arumugam Selva Sharma, Malaichamy Ilanchelian
Sep 4, 2015·The AAPS Journal·Murali M YallapuSubhash C Chauhan
Nov 16, 2016·Nature Communications·Maria Cristina Lo GiudiceKenneth A Dawson
Nov 17, 2017·Nature Communications·Monica CarrilWolfgang J Parak

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Citations

Jul 25, 2020·Journal of Liposome Research·Himadri Gourav BehuriaSantosh Kumar Sahu
Jul 10, 2019·Anti-cancer Agents in Medicinal Chemistry·Manjula Vinayak, Akhilendra K Maurya
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qi-Yao WeiAndy T Y Lau

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Methods Mentioned

BETA
transmission
dynamic light scattering
surface plasmon resonance
Circular dichroism
atomic absorption spectroscopy

Software Mentioned

GraphPad
GraphPad Prism

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