Phytochemicals as potent modulators of autophagy for cancer therapy

Cancer Letters
Mohammad Amin MoosaviAtanas G Atanasov

Abstract

The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy.

Citations

Dec 12, 2019·Future Medicinal Chemistry·Xiaoxia LiangBo Jing
Mar 4, 2020·Cancers·Chandramohan KiruthigaAnupam Bishayee
Oct 18, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yang WangYuan Zhang
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dongdong WangAtanas G Atanasov
Apr 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adrian Bogdan ȚiguMarcel Pârvu
Feb 8, 2019·Oxidative Medicine and Cellular Longevity·Andy Wai Kan YeungAtanas G Atanasov
Jan 5, 2020·Critical Reviews in Food Science and Nutrition·Oswaldo Pablo Martínez-RodríguezMaría Eugenia Jaramillo-Flores
Mar 25, 2019·Journal of Cancer Research and Clinical Oncology·Andrea KapinovaJan Danko
May 26, 2020·Seminars in Cancer Biology·Srimanta PatraSujit K Bhutia
Dec 15, 2020·Oxidative Medicine and Cellular Longevity·Chang Min LeeSee-Hyoung Park
Feb 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Julia QuartiVivian M Rumjanek
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Khalid El BairiSaid Afqir
Jun 8, 2021·Biotechnology Reports·Srimanta PatraMrutyunjay Jena
Jun 8, 2021·Molecular Therapy Oncolytics·Zhixia ZhouPeifeng Li
Aug 10, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Srimanta PatraSujit Kumar Bhutia
Feb 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chao-Yue SunBing Feng

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