Phytochemistry and antiplasmodial activity of Xylopia sericea leaves

Natural Product Research
Douglas Costa GontijoAlaíde B Oliveira

Abstract

Aiming to investigate the antiplasmodial activity and the phytochemical composition of Xylopia sericea leaves, the essential oil and dichloromethane extract were analyzed by gas and liquid chromatography, respectively, both of them coupled to mass spectrometry, and were evaluated against the chloroquine-resistant Plasmodium falciparum strain (W2) and for cytotoxicity to HepG2 cells. Low growth inhibition of P. falciparum as well as low cytotoxicity to HepG2 cells were observed for the essential oil. The leaves dichloromethane extract showed moderate growth inhibition of P. falciparum and low cytotoxicity to HepG2 cells. Bioguided chromatographic fractionation of this extract led to fractions with increased antiplasmodial activity from which liriodenine (IC50 6.1 ± 0.1 μg/mL, CC50 > 1000.0 μg/mL, SI > 164), an aporphine alkaloid, and an acetogenin-rich fraction containing mainly isomers of annomontacin and 4-deoxy-annomontacin (IC50 22.7 ± 1.9 µg/mL, CC50 336.1 ± 15.5 µg/mL, SI = 15) might be highlighted for their antiplasmodial activity.

References

Apr 1, 1994·Journal of Natural Products·T Colman-SaizarbitoriaJ L McLaughlin
Jun 1, 1993·The American Journal of Tropical Medicine and Hygiene·M T MaklerD J Hinrichs
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Herbert Rodrigues GoulartAlejandro M Katzin
Feb 9, 2016·Journal of Natural Products·David J Newman, Gordon M Cragg

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Methods Mentioned

BETA
column chromatography

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