Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.

Phytochemical Analysis : PCA
Tanja GödeckeGuido F Pauli

Abstract

Earlier studies reported serotonergic activity for cimicifugic acids (CA) isolated from Cimicifuga racemosa. The discovery of strongly basic alkaloids, cimipronidines, from the active extract partition and evaluation of previously employed work-up procedures has led to the hypothesis of strong acid/base association in the extract. Re-isolation of the CAs was desired to permit further detailed studies. Based on the acid/base association hypothesis, a new separation scheme of the active partition was required, which separates acids from associated bases. A new 5-HT(7) bioassay guided work-up procedure was developed that concentrates activity into one partition. The latter was subjected to a new two-step centrifugal partitioning chromatography (CPC) method, which applies pH zone refinement gradient (pHZR CPC) to dissociate the acid/base complexes. The resulting CA fraction was subjected to a second CPC step. Fractions and compounds were monitored by (1)H NMR using a structure-based spin-pattern analysis facilitating dereplication of the known acids. Bioassay results were obtained for the pHZR CPC fractions and for purified CAs. A new CA was characterised. While none of the pure CAs was active, the serotonergic activity was concent...Continue Reading

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Citations

Dec 19, 2012·Journal of Natural Products·Shi-Hui DongShao-Nong Chen
Feb 18, 2009·Journal of Natural Products·Tanja GödeckeGuido F Pauli
Jan 14, 2016·Journal of Natural Products·Ayano ImaiGuido F Pauli
Jul 16, 2015·Journal of Natural Products·J Brent FriesenGuido F Pauli
Aug 11, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jinghu LiDejan Nikolić
Nov 20, 2018·Journal of Asian Natural Products Research·Jing LuMing-Hua Qiu
Dec 2, 2014·Hormone Molecular Biology and Clinical Investigation·Dana Seidlova-WuttkeWolfgang Wuttke
Nov 10, 2020·Phytotherapy Research : PTR·Nirit BernsteinMuhammad Daniyal
Oct 20, 2010·The Medical Journal of Australia·Scott C McKenzie, Atifur Rahman

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